CD59 Monoclonal Antibody

Datasheet
Code CSB-MA0049471A0m
Product Type Monoclonal Antibody
Size US$350Purchase it in Cusabio online store
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Uniprot No. P13987
Image
  • Immunohistochemical of paraffin-embedded Human breast cancer using CSB-MA0049471A0m (2E11-2B5) at dilution of 1:200.

  • Immunohistochemical of paraffin-embedded human placenta tissue using CSB-MA0049471A0m (2E11-2B5) at dilution of 1:200.

  • All lanes: Mouse Anti-CD59 monoclonal antibody at 1μg/ml
    Lane 1:K562
    Predicted band size : 15kd
    Observed band size : 22kd

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant CD59 Protein
Raised in mouse
Species Reactivity Human
Specificity specific for Recombinant CD59 Protein denatured and native forms
Tested Applications ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500
Relevance CD59, also named as MIC11, MIN1, MIN2, MIN3, MSK21, MIRL, MACIF, HRF20 and 1F5 antigen, is a cell surface molecule glycoprotein with MW 18-25kd. It acts as a determinant of proximal–distal cell identity. CD59 acts by binding to the C8 and/or C9 complements of the assembling membrane attack complex (MAC), thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. It is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Form liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%,protein G purifed
Isotype IgG1
Clonality monoclonal
Alias CD59 glycoprotein,HRF-20,MAC-IP,MACIF,MIRL,CD59
Immunogen Species Homo sapiens (Human)
Gene Names CD59
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Clone No. 2E11B6
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Function Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; FUNCTION
Involvement in disease Hemolytic anemia, CD59-mediated, with or without polyneuropathy (HACD59)
Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor, Secreted
Database Links

HGNC: 1689

OMIM: 107271

KEGG: hsa:966

STRING: 9606.ENSP00000340210

UniGene: Hs.278573

Pathway Complement and coagulation cascades
Hematopoietic cell lineage

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