Recombinant Human SPARC protein(SPARC) (Active)

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Code CSB-AP000311HU
Product Type Other
Size US$112Purchase it in Cusabio online store
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Uniprot No. P09486
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Basement-membrane protein 40, Osteonectin, ON, Secreted protein acidic and rich in cysteine
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the cell growth of Mv1Lu mink lung epithelial cells is less than 3.0 ug/mL, corresponding to a specific activity of >333 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence MSYYHHHHHH DYDIPTTENL YFQGAMGSA+P QQEALPDETE VVEETVAEVT EVSVGANPVQ VEVGEFDDGA EETEEEVVAE NPCQNHHCKH GKVCELDENN TPMCVCQDPT SCPAPIGEFE KVCSNDNKTF DSSCHFFATK CTLEGTKKGH KLHLDYIGPC KYIPPCLDSE LTEFPLRMRD WLKNVLVTLY ERDEDNNLLT EKQKLRVKKI HENEKRLEAG DHPVELLARD FEKNYNMYIF PVHWQFGQLD QHPIDGYLSH TELAPLRAPL IPMEHCTTRF FETCDLDNDK YIALDEWAGC FGIKQKDIDK DLVI
Research Area Cancer
Source E.coli
Gene Names SPARC
Expression Region 18-303aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 36.1 kDa
Protein Description Full Length of Mature Protein
PubMed ID 3410046; 2838412; 2790009; 2338025; 15489334; 17974005; 3597437; 2306517; 3400777; 7495300; 9457905; 8548457; 9233787; 9501084
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Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Involvement in disease Osteogenesis imperfecta 17 (OI17)
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane
Protein Families SPARC family
Database Links

HGNC: 11219

OMIM: 182120

KEGG: hsa:6678

STRING: 9606.ENSP00000231061

UniGene: Hs.111779

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