Recombinant Mouse Uteroglobin protein(Scgb1a1) (Active)

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Code CSB-AP000561MO
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Product Details

Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/m.
Target Names Scgb1a1
Uniprot No. Q06318
Research Area Immunology
Alternative Names Scgb1a1; Cc10; Ugb; Utg; Uteroglobin; Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; PCB-binding protein; Secretoglobin family 1A member 1
Species Mus musculus (Mouse)
Source E.Coli
Expression Region 22-96aa
Mol. Weight 8.4 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 150mM NaCl
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time 5-10 business days
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

(From Uniprot)
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Gene References into Functions
  1. the present results demonstrate that rCC16 has therapeutic effects on COPD by downregulating proinflammatory factors via the NFkappaB pathway. PMID: 29956762
  2. This study extends the function of the Scgb1a1-expressing epithelial cell population as a major mediator of the antiviral response. It PMID: 29593031
  3. Chronic P. aeruginosa inflammation resulted in chronic bronchitis and emphysematous changes in CCSP-deficient mice. PMID: 27703342
  4. CC16 protects lungs from cigarette smoke (CS)-induced injury by reducing lung NF-kappaB activation. CS-induced airway CC16 deficiency increases CS-induced pulmonary inflammation and injury and likely contributes to the pathogenesis of COPD. PMID: 25700379
  5. Depletion of bone marrow CCSP-expressing cells delays airway regeneration. PMID: 25409745
  6. Serum CC-16 is associated with disease progression in chronic obstructive pulmonary disease (COPD). However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice. PMID: 24245748
  7. These findings indicate that CCSP has a regulatory role in obliterative bronchiolitis. PMID: 23997179
  8. the role of clara cells and clara cell secretory protein in lung radiation injury exacerbated by viral infection PMID: 23621375
  9. AAV2/9-CC10 vector virus guaranteed sufficient CC10 expression and had an anti-inflammatory effect in asthmatic mice. PMID: 23013277
  10. Claudin-3 and Clara cell 10 kDa protein were identified as possible markers of early tobacco smoke-induced epithelial injury along alveolar ducts. PMID: 22659244
  11. Scgb1a1-expressing cells, most likely Clara cells, are a major cell type that gives rise to alveolar type I and II cells during the regeneration of alveolar epithelia in response to severe pulmonary damage in mice. PMID: 23119022
  12. These results indicate that CC10 gene transfer may inhibit airway inflammation through suppressing the activation of NF-kappaB. PMID: 22558282
  13. Clara cell secretory protein expression is elevtaed in lungs after long-term n-hexane inhalation exposure. PMID: 20853679
  14. CCSP promoter has a role in alveolar development PMID: 20693404
  15. The expression of CC10 is downregulated in sinonasal mucosa in bacterial chronic rhinosinusitis. PMID: 19119605
  16. Expression of SCGB1A1 mRNA was not decreased in vivo in the absence of C/EBPs. PMID: 21224212
  17. The differential expression of mRNA by both airway level and lung region was determined for Clara cell secretory protein. PMID: 20852037
  18. Lack of uteroglobin in mice enhances colonization of B16F10 melanoma cells in the lungs. PMID: 20118237
  19. macrophages from Clara cell-depleted and CCSP(-/-) mice displayed increased Toll-like receptor 4 surface expression PMID: 19423773
  20. Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells PMID: 11817538
  21. Data show that Clara cell secretory protein (CCSP) is required for the appearance of secretory granules and that functional changes to Clara cells that result from CCSP deficiency lead to alterations in the composition of epithelial lining fluid. PMID: 12151308
  22. demonstrate synergistic transactivation by C/EBPalpha and Nkx2.1 in the regulation of the CCSP gene PMID: 12161423
  23. An immunohistochemical analysis was made of the expression of this protein in a transgenic model of mouse lung carcinogenesis. PMID: 12699910
  24. Restoration of CCSP in the airways of CCSP-deficient mice abrogates the increase in viral persistence, lung inflammation, and airway hyperreactivity induced by respiratory syncytial virus infection. PMID: 12847279
  25. Multiple mechanisms for repression of the Clara cell secretory protein gene during hyperoxia. PMID: 14500549
  26. Data show that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone exposure of Clara cell 10-kDa protein knock-out mice causes a significantly higher incidence of airway epithelial hyperplasia and lung adenomas compared with wild type littermates. PMID: 15148323
  27. plays a direct role in the regulation of T-cell-mediated inflammatory responses. PMID: 15356574
  28. We propose that mechanical activation of the cPLA2 pathway contributes to acute high PIP-induced lung injury and that CCSP may reduce this injury through inhibition of the cPLA2 pathway and reduction of proinflammatory products produced by this pathway. PMID: 15608088
  29. Uteroglobin suppresses SCCA gene expression associated with airway inflammation in asthma PMID: 15677460
  30. uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor PMID: 16061484
  31. A critical role for uteroglobin in preventing the development of pulmonary fibrosis. PMID: 16872605
  32. These results suggest that both long- and short-range paracrine signaling between nonciliated secretory cells and cells of the immune system and epithelium impact modification of cell type-specific proteins. PMID: 17384087
  33. Treatment of lung neoplasms with bexarotene resulted in decreased mRNA expression. PMID: 17849452
  34. Clara cells accumulated Clara cell secretory protein (CCSP) in Munc13-2-deficient mice. PMID: 18258655
  35. preferentially expressed in mouse model of allergen-induced airway inflammation and remodeling PMID: 19322781

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Subcellular Location Secreted
Protein Families Secretoglobin family
Tissue Specificity Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Database Links

KEGG: mmu:22287

STRING: 10090.ENSMUSP00000025554

UniGene: Mm.2258


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