A4GALT Antibody

Code CSB-PA868276ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA868276ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA868276ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) A4GALT Polyclonal antibody
Uniprot No.
Target Names
A4GALT
Alternative Names
4 N acetylglucosaminyltransferase antibody; 4-galactosyltransferase antibody; 4-N-acetylglucosaminyltransferase antibody; A14GALT antibody; A4GALT antibody; A4GALT1 antibody; A4GAT_HUMAN antibody; Alpha 1 4 galactosyltransferase antibody; Alpha 1 4 N acetylglucosaminyltransferase antibody; Alpha-1 antibody; Alpha4Gal T1 antibody; Alpha4Gal-T1 antibody; CD77 synthase antibody; Gb3 synthase antibody; Gb3S antibody; Globotriaosylceramide synthase antibody; Lactosylceramide 4 alpha galactosyltransferase antibody; Lactosylceramide 4-alpha-galactosyltransferase antibody; P blood group (P one antigen) antibody; P(k) antigen synthase antibody; P1 antibody; P1/Pk synthase antibody; PK antibody; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase antibody; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Lactosylceramide 4-alpha-galactosyltransferase protein (244-353AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes. Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P.; (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.
Gene References into Functions
  1. The differential binding of transcription factor early growth response 1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression. PMID: 29399809
  2. A4GALT SNPs spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system PMID: 29709005
  3. Study reports a novel mutation in the A4GALT gene that was responsible for a p phenotype in a Chinese individual. PMID: 27612185
  4. amino acid residue at position 211 of Gb3/CD77 synthase is critical for specificity and activity of the enzyme involved in formation of P(k), P1 and NOR antigens. Altogether, this approach affords a new insight into the mechanism of action of the human Gb3/CD77 synthase. PMID: 27538840
  5. This is the first direct biochemical evidence that Gb3/CD77 synthase is able to synthesize two different glycosphingolipid antigens: P(k) and P1, and when p.Q211E substitution is present, the NOR antigen is also synthesized. PMID: 26773500
  6. Mutation in the A4GALT gene is associated with rare p phenotype in P1Pk blood group system. PMID: 25863098
  7. The results of this investigation demonstrate a consistent association of A4GALT SNPs rs2143918 and rs5751348 with the P1/P2 phenotypes and suggest that SNP rs5751348 may lead to allelic variations in A4GALT gene expression PMID: 25041587
  8. these data elucidate a new explanation underlying the p phenotype, implicating the deleted regions of A4GALT as crucial for P1 and P(k) synthesis, possibly due to loss of binding sites for erythroid transcription factors. PMID: 24417201
  9. P1-decorated PSGL-1/mIgG2b bound with high avidity to both Stx1 and Stx2, and as such constitutes a potential therapeutic inhibitor of these toxins. PMID: 24082034
  10. several P1PK-null alleles were identified. PMID: 23927681
  11. Results suggest that the C631G mutation alters the acceptor specificity of Gb3/CD77 synthase, rendering it able to catalyze synthesis of the Gal(alpha1-4)Gal and Gal(alpha1-4)GalNAc moieties. PMID: 22965229
  12. Increased globotriaosylceramide levels are detected in a transgenic mouse expressing human alpha1,4-galactosyltransferase in a mouse model for treating Fabry disease. PMID: 20961863
  13. 2 Taiwanese individuals with p phenotype were homozygous for a & 428. No expression of P(k) & no enzyme activity were observed in cells transfected with the mutant construct. PMID: 21092013
  14. Total urinary protein isoforms of globotriaosylceramide were used to identify Fabry disease in women. PMID: 21186071
  15. Data showed that GRINA-C was associated with Gb3 synthase, and may demonstrate a new type of posttranscriptional regulation of glycosyltransferases. PMID: 20837469
  16. of A4GALT mRNA in cultured human bone marrow cells revealed novel transcripts containing only the noncoding exon 1 and a sequence (here termed exon 2a) from intron 1. PMID: 20971946
  17. We established by quantitative real-time PCR that both fresh colonic epithelial sections and HCT-8 cells express Gb3 synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide. PMID: 20732996
  18. expression in megakaryoblastic leukemia cells PMID: 11782470
  19. The P blood group phenotype is due to several disctint nonfunctional alleles of A4GALT without any predominant allele. PMID: 11896312
  20. results strongly suggested that P1 synthase is identical to Gb3/CD77 synthase PMID: 12888565
  21. Data show that a novel A4GALT missense mutation causes the p phenotype in Amish individuals. PMID: 18067504
  22. the transcriptional regulation of the Gb3S gene by Sp1 might affect the verotoxin sensitivity of endothelial cell and Hemolytic uremic syndrome progression. PMID: 18757779
  23. P(k) expression strongly influences susceptibility to HIV-1 infection, which implicates P(k) as a new endogenous cell-surface factor that may provide protection against HIV-1 infection. PMID: 19139081
  24. These data show that globotriaosylceramide (Gb3) content, which is regulated by the expression of Gb3 synthase, determines the sensitivity of HeLa cells toward Shiga toxin. PMID: 19470247

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Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 32 family
Tissue Specificity
Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
Database Links

HGNC: 18149

OMIM: 111400

KEGG: hsa:53947

STRING: 9606.ENSP00000249005

UniGene: Hs.105956

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