A4GALT Antibody

Datasheet
Code CSB-PA868276ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA868276ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA868276ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) A4GALT Polyclonal antibody
Uniprot No. Q9NPC4
Target Names A4GALT
Alternative Names 4 N acetylglucosaminyltransferase antibody; 4-galactosyltransferase antibody; 4-N-acetylglucosaminyltransferase antibody; A14GALT antibody; A4GALT antibody; A4GALT1 antibody; A4GAT_HUMAN antibody; Alpha 1 4 galactosyltransferase antibody; Alpha 1 4 N acetylglucosaminyltransferase antibody; Alpha-1 antibody; Alpha4Gal T1 antibody; Alpha4Gal-T1 antibody; CD77 synthase antibody; Gb3 synthase antibody; Gb3S antibody; Globotriaosylceramide synthase antibody; Lactosylceramide 4 alpha galactosyltransferase antibody; Lactosylceramide 4-alpha-galactosyltransferase antibody; P blood group (P one antigen) antibody; P(k) antigen synthase antibody; P1 antibody; P1/Pk synthase antibody; PK antibody; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase antibody; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Lactosylceramide 4-alpha-galactosyltransferase protein (244-353AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
Gene References into Functions
  1. The differential binding of transcription factor early growth response 1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression. PMID: 29399809
  2. A4GALT SNPs spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system PMID: 29709005
  3. Study reports a novel mutation in the A4GALT gene that was responsible for a p phenotype in a Chinese individual. PMID: 27612185
  4. amino acid residue at position 211 of Gb3/CD77 synthase is critical for specificity and activity of the enzyme involved in formation of P(k), P1 and NOR antigens. Altogether, this approach affords a new insight into the mechanism of action of the human Gb3/CD77 synthase. PMID: 27538840
  5. This is the first direct biochemical evidence that Gb3/CD77 synthase is able to synthesize two different glycosphingolipid antigens: P(k) and P1, and when p.Q211E substitution is present, the NOR antigen is also synthesized. PMID: 26773500
  6. Mutation in the A4GALT gene is associated with rare p phenotype in P1Pk blood group system. PMID: 25863098
  7. The results of this investigation demonstrate a consistent association of A4GALT SNPs rs2143918 and rs5751348 with the P1/P2 phenotypes and suggest that SNP rs5751348 may lead to allelic variations in A4GALT gene expression PMID: 25041587
  8. these data elucidate a new explanation underlying the p phenotype, implicating the deleted regions of A4GALT as crucial for P1 and P(k) synthesis, possibly due to loss of binding sites for erythroid transcription factors. PMID: 24417201
  9. P1-decorated PSGL-1/mIgG2b bound with high avidity to both Stx1 and Stx2, and as such constitutes a potential therapeutic inhibitor of these toxins. PMID: 24082034
  10. several P1PK-null alleles were identified. PMID: 23927681
  11. Results suggest that the C631G mutation alters the acceptor specificity of Gb3/CD77 synthase, rendering it able to catalyze synthesis of the Gal(alpha1-4)Gal and Gal(alpha1-4)GalNAc moieties. PMID: 22965229
  12. Increased globotriaosylceramide levels are detected in a transgenic mouse expressing human alpha1,4-galactosyltransferase in a mouse model for treating Fabry disease. PMID: 20961863
  13. 2 Taiwanese individuals with p phenotype were homozygous for a & 428. No expression of P(k) & no enzyme activity were observed in cells transfected with the mutant construct. PMID: 21092013
  14. Total urinary protein isoforms of globotriaosylceramide were used to identify Fabry disease in women. PMID: 21186071
  15. Data showed that GRINA-C was associated with Gb3 synthase, and may demonstrate a new type of posttranscriptional regulation of glycosyltransferases. PMID: 20837469
  16. of A4GALT mRNA in cultured human bone marrow cells revealed novel transcripts containing only the noncoding exon 1 and a sequence (here termed exon 2a) from intron 1. PMID: 20971946
  17. We established by quantitative real-time PCR that both fresh colonic epithelial sections and HCT-8 cells express Gb3 synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide. PMID: 20732996
  18. expression in megakaryoblastic leukemia cells PMID: 11782470
  19. The P blood group phenotype is due to several disctint nonfunctional alleles of A4GALT without any predominant allele. PMID: 11896312
  20. results strongly suggested that P1 synthase is identical to Gb3/CD77 synthase PMID: 12888565
  21. Data show that a novel A4GALT missense mutation causes the p phenotype in Amish individuals. PMID: 18067504
  22. the transcriptional regulation of the Gb3S gene by Sp1 might affect the verotoxin sensitivity of endothelial cell and Hemolytic uremic syndrome progression. PMID: 18757779
  23. P(k) expression strongly influences susceptibility to HIV-1 infection, which implicates P(k) as a new endogenous cell-surface factor that may provide protection against HIV-1 infection. PMID: 19139081
  24. These data show that globotriaosylceramide (Gb3) content, which is regulated by the expression of Gb3 synthase, determines the sensitivity of HeLa cells toward Shiga toxin. PMID: 19470247

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Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families Glycosyltransferase 32 family
Tissue Specificity Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
Database Links

HGNC: 18149

OMIM: 111400

KEGG: hsa:53947

STRING: 9606.ENSP00000249005

UniGene: Hs.105956

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