ABCC3 Antibody

Code CSB-PA001062LA01HU
Size US$299
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  • Immunofluorescent analysis of A549 cells using CSB-PA001062LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ABCC3 Polyclonal antibody
Uniprot No. O15438
Target Names ABCC3
Alternative Names ABC 31 antibody; ABC31 antibody; ABCC 3 antibody; ABCC3 antibody; ATP binding cassette sub family C (CFTR/MRP) member 3 antibody; ATP binding cassette sub family C member 3 antibody; ATP-binding cassette sub-family C member 3 antibody; Canalicular multispecific organic anion transporter 2 antibody; Canicular multispecific organic anion transporter antibody; CMOAT 2 antibody; CMOAT2 antibody; EST90757 antibody; MLP 2 antibody; MLP2 antibody; MOAT D antibody; MOAT-D antibody; MOATD antibody; MRP 3 antibody; MRP3_HUMAN antibody; Multi specific organic anion transporter D antibody; Multi-specific organic anion transporter D antibody; Multidrug resistance associated protein 3 antibody; Multidrug resistance associated protein antibody; Multidrug resistance-associated protein 3 antibody; Multispecific organic anion tranporter D antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Canalicular multispecific organic anion transporter 2 protein (827-953AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Gene References into Functions
  1. CGI may function as an enhancer of the transcription of ABCC3. PMID: 29437875
  2. Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3). PMID: 29545174
  3. Data show that bladder cancer is associated with perturbed expression of MRP3 and BCRP. PMID: 28586062
  4. Histological subtype of epithelial ovarian cancer correlated with the expression of PgP, MRP1, and MRP3. The lowest level of Pgp and MRP1 expression was found in endometrioid ovarian cancers PMID: 27739315
  5. miR-148a-siRNA and rifampin inhibited estradiol upregulation of MRP3 expression. miR-148a may be involved in the estrogen induction in intrahepatic cholestasis of pregnancy via PXR signaling. MRP3 may be involved. PMID: 28575098
  6. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. PMID: 26810133
  7. PXR is a potential biomarker for predicting outcome and activates MRP3 transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC. PMID: 28356150
  8. This study highlights the importance of ABCC3 transporters in drug resistance to chemotherapy in the context of breast cancer. PMID: 27171227
  9. Wnt signaling regulates ABCC3 expression in colon cancer cells, with the ABCC3 locus being a target of the transcription factors TCF7L2 and beta-catenin. PMID: 27709738
  10. ABCC3 is an important oncoprotein involved in glycolysis and drug resistance PMID: 26733163
  11. This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma PMID: 26337276
  12. High MRP expression is associated with sorafenib resistance in hepatocellular carcinoma. PMID: 26769852
  13. ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response. PMID: 26107220
  14. Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism. PMID: 25788542
  15. ABCC3 expression may serve as a marker for MDR and predictor for poor clinical outcome of NSCLC. PMID: 24176985
  16. A functional Nrf2 response element within the eighth intron of the ABCC3 gene. PMID: 25349122
  17. Renal function of MRP3 is related to renal cell proliferation and cyst formation and that restoring MRP3 may be an effective therapeutic approach for polycystic kidney disease. PMID: 25143454
  18. These results suggest that carboplatin and paclitaxel may induce drug resistance mediated by MDR1 and MRP3, which may be enhanced by the simultaneous use of both drugs. PMID: 23443122
  19. ABCC3 promoter methylation does not seem to exhibit any impact on maximum platelet aggregation and clopidogrel response at all PMID: 25985567
  20. Epidermal growth factor - mediated epithelial-mesenchymal transition induces ABCC3 mRNA in MDA-MB-468 breast cancer cells. The process is calcium dependant. PMID: 25666946
  21. Our data suggest that besides bodyweight, OCT1 and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children PMID: 25155932
  22. for ABCC3 variants, little evidence, if any, was found for an association of drug response to genetic variants PMID: 25162314
  23. variants of ABCB1 rs128503, ABCC3 rs4148416, and GSTP1 rs1695 are associated with response to chemotherapy and survival of osteosarcoma patients PMID: 24996541
  24. Aberrant expression of MRP3 in rectal cancer confers chemo-radioresistance. PMID: 25088576
  25. ABCC3 rs4148416 TT polymorphism is associated with poor response to chemotherapy in bone tumors. PMID: 24083708
  26. our results suggest that fusion protein scFvM58-sTRAIL with specificity for MRP3 is a highly selective therapeutic agent and may provide an alternative therapy for human Glioblastoma multiforme . PMID: 24272336
  27. The ABCC3 -211C/T polymorphism seems not to be associated with altered antiplatelet effects and clinical outcomes in clopidogrel-treated patients. PMID: 23692149
  28. A predictive model combining variants in TPMT, ABCC3, and COMT with clinical variables significantly improved the prediction of hearing-loss development as compared with using clinical risk factors alone PMID: 23588304
  29. Induction of MRP3 expression by 17alpha-ethynylestradiol requires recruitment of estrogen receptor-alpha and activator protein-1. PMID: 23747343
  30. human cornea models possessed MRP3 and BCRP expression, whereas no functional expression was found in rabbit and porcine corneas. PMID: 23069916
  31. Stimulation of ATPase and substrate translocation show positive cooperativity. Maximal stimulation of ATPase activity is substrate independent. PMID: 23176825
  32. Increased MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas. PMID: 22767273
  33. MRP3 A-189 T polymorphism was associated with treatment responses in acute lymphoblastic leukemia , likely due to the change in MRP3 efflux. PMID: 21606946
  34. Anti-ABCC3 IgA and IgG were determined using an enzyme-linked immunosorbent assay (ELISA) approach. PMID: 22699933
  35. Amplification and overexpression of the ABCC3 gene is associated with primary breast cancer. PMID: 22585709
  36. up-regulation of hepatic MRP3/ABCC3 expression in human obstructive cholestasis is likely triggered by TNFalpha, mediated by activation of JNK/SAPK and SP1. PMID: 22105759
  37. Findings show that the gene expression of ATP-dependent efflux transporters MRP1, -3, -4, -5, and p-gp fluctuated during stem cell-derived retinal pigment epithelial cells (hESC-RPE) maturation. PMID: 22272278
  38. We demonstrate direct involvement between nuclear factor erythroid-2-related factor 2 and the MRP3 promoter, which leads to the up-regulation of the MRP3 gene. PMID: 22089114
  39. investigation of vectorial transport across enterocytes: Data from Caco-2 cell monolayers, models for intestinal absorption, suggest that MRP3 mediates fexofenadine/zwitterion efflux across basolateral membrane. PMID: 21780830
  40. study identified genetic polymorphisms of ABCC3 and evaluated their effects on ABCC3 expression and MRP3 function; 61 genetic variants were identified in three ethnic populations; of these variants 17 were novel PMID: 21512263
  41. effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy PMID: 22016816
  42. Low ABCC3 expression was associated with reduced event-free survival of neuroblastoma patients. PMID: 21799180
  43. Used a spin-labeled ATP analog, SL-ATP, to study nucleotide binding to highly purified human multidrug resistance protein 3, MRP3. PMID: 20563633
  44. Immunohistochemical evaluation of human gliomas to determine the localization of MRP3 antigen using scFvs M25 and M58 showed a dense cytoplasmic and membranous staining pattern PMID: 19937796
  45. MDR1, MRP2, MRP3 and MRP5 levels are decreased by tetramethylpyrazine in human hepatocellular carcinoma cells PMID: 19956884
  46. Expression of MRP3 can be induced by certain nonsteroidal anti-inflammatory drugs (e.g., indomethacin) in a reactive oxygen species-dependent but cyclooxygenase-2-independent manner. PMID: 11820781
  47. tissue distribution and induction in normal human tissues and in cholestasis PMID: 11850532
  48. possible role in the removal of bile acids from the liver in cholestasis PMID: 12220224
  49. down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated. PMID: 12628490
  50. MRP3 active transport of estradiol-17-beta-d-glucuronide and MRP3 ATPase characteristics in isolated, inside-out membrane vesicles PMID: 12704183
  51. Genetic polymorphisms in the MRP3 is associated with liver neoplasms PMID: 15167703
  52. Upregulation of MRP3 expression is associated with pancreatic carcinoma PMID: 15688370
  53. MRP3, BCRP, and P-glycoprotein have roles in progression of adult acute myeloid leukemia PMID: 16278398
  54. a polymorphism -211C>T in the promoter region of MRP3 does not determine the expression level of the gene in acute leukemia PMID: 16424827
  55. evidence that clearly indicates that glyburide is preferentially transported by BCRP and MRP3 PMID: 16460798
  56. The mRNA induction of MDR1, MRP1, MRP2 and MRP3 by rifampicin (Rif), dexamethasone (Dex) and omeprazole (Ome) was investigated in primary cultures of cryopreserved human and rat hepatocytes. PMID: 16946557
  57. our results indicate that activator Sp1 and repressor RXRalpha:RARalpha act in concert to regulate MRP3 expression. loss of RXRalpha:RARalpha may lead to upregulation of MRP3/Mrp3 expression in cholestatic liver injury. PMID: 17272513
  58. The ABCC3 -211C>T polymorphism does not affect promotor activity nor FTF transcription factor binding. PMID: 17300812
  59. Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo. PMID: 17485564
  60. MRP1-Pro(1150), MRP2-Pro(1158), and MRP3-Pro(1147) in the cytoplasmic loop 7 differ in their influence on substrate specificity but share a common role in the nucleotide interactions at nucleotide binding domain 2 of these transporters. PMID: 17494643
  61. in this study, the 31 ABCC3 exons and their flanking introns were comprehensively screened for genetic variations in 89 Japanese subjects; forty-six genetic variations, including 21 novel ones, were found PMID: 17495421
  62. induction of ABCC2 and ABCG2 by tBHQ is mediated by the Nrf2/Keap1 system, whereas the induction of ABCC1 may involve a Keap1-dependent but Nrf2-independent mechanism. PMID: 18038766
  63. Polymorphisms in ABCC3 is associated with acute myeloid leukemia PMID: 18207572
  64. No significant association was found between the two ABCC3 polymorphisms and colorectal cancer risk. PMID: 18313914
  65. ABCC3 is a mediator of taxane resistance in HER2-amplified breast cancer. PMID: 18593940
  66. MRP3 could be a novel molecular marker for localized non-mucinous bronchioloalveolar carcinoma, whose expression increases during the early progression of tumourigenesis PMID: 18604784
  67. Single nucleotide polymorphisms in the ABCC3 gene is associated with acquisition of hepatotoxicity, due to their poor ability to transport toxic compounds PMID: 18698235
  68. the expression of MRP(multiple drug resistance-associated protein)1, MRP2, and MRP3 molecules in systemic lupus erythematosus mononuclear cells was not different from normal PMID: 18799096
  69. MRP3, MRP4, and MRP5 are upregulated in 5-fluorouracil-resistant cells, and MRP5 contributes to 5-FU resistance in pancreatic carcinoma cells. PMID: 19077464
  70. ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients. PMID: 19107936
  71. Vectorial transport of resveratrol metabolites is mediated by multidrug resistance protein 3 (MRP3, ABCC3) located in the basolateral membranes of enterocytes. PMID: 19114588
  72. analysis of positive allosteric cooperativity for ABCC3-mediated substrate translocation PMID: 19334674
  73. MRP3 induction was dependent upon the transcription factor Nrf2 PMID: 19345732
  74. Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers. PMID: 19480556

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
Database Links

HGNC: 54

OMIM: 604323

KEGG: hsa:8714

STRING: 9606.ENSP00000285238

UniGene: Hs.463421

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