Product Details

Uniprot No.

Target Names

ADD2

Alternative Names

ADD 2 antibody; ADD2 antibody; ADDB antibody; ADDB_HUMAN antibody; Adducin 2 (beta) antibody; Adducin2 antibody; Beta adducin antibody; Beta-adducin antibody; Erythrocyte adducin subunit beta antibody; OTTHUMP00000203378 antibody; OTTHUMP00000203908 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human ADD2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:15-1:50

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
Gene References into Functions	betaadducin was demonstrated to have a critical role in neutrophil migration. PMID: 29901076 Aberrant DNA methylation of ADD2 could be potential screening markers of colorectal cancer. PMID: 27493446 Study evaluated effects of ADD genetic variability on cognitive functions in a sample of patients with schizophrenia, known to show a wide and heterogeneous neuropsychological deficit and found that ADD2 C1797T polymorphism showed diffuse effects on almost every cognitive domain. PMID: 26723519 ADD2 and NCX1 variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis. PMID: 26045217 Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1-mediated neutrophil rolling on P-selectin. PMID: 25425738 phosphorylation of beta-adducin by GSK3 promotes efficient neurite outgrowth in neurons. PMID: 21606488 there was significant heterogeneity between Slavic and Italian subjects in the phenotype-genotype relationships with beta-adducin PMID: 14553963 Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase activity, mu2-subunit hyperphosphorylation, and impaired Na+,K+-ATPase endocytosis. PMID: 15528469 Polymorphisms in the ADD2 and ADD3 genes taken alone were not associated with blood pressure and renin activity PMID: 15716695 The very high levels of expression of ADD2 suggest that its promoter may be useful for directing erythroid-specific gene expression. PMID: 15963851 beta-adducin is a downstream target of and regulated by the PTN/RPTPbeta/zeta signaling pathway PMID: 16105548 Changes in intra-erythrocyte cations in ADD2 1797CC homozygous men might lead to osmotic fragility of erythrocytes, but to what extent they reflect systemic changes or are possibly involved in blood pressure regulation remains unknown. PMID: 17301826 hypertension candidate gene variation may influence BP responses to specific antihypertensive drug therapies and measurement of genetic variation may assist in identifying subgroups of hypertensive patients benefiting from antihypertensive drug therapies PMID: 17854487 Show More Hide All
Subcellular Location	Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families	Aldolase class II family, Adducin subfamily
Tissue Specificity	Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.
Database Links	HGNC: 244 OMIM: 102681 KEGG: hsa:119 STRING: 9606.ENSP00000264436 UniGene: Hs.188528

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Check Code：

Code	CSB-PA154092
Size	US$299 How to order?
Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA154092(ADD2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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ADD2 Antibody

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