APOBEC1 Antibody

1. Our findings propose APOBEC1 and isoform b as the potential endogenous mutators implicated in cancer in-frame indels and pave the way for their use as novel prognostic tumor markers. PMID: 29346513
2. Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells. PMID: 28639893
3. AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review) PMID: 26398702
4. Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models. PMID: 25085003
5. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in esophageal squamous cell carcinoma. PMID: 25839328
6. hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
7. Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4). PMID: 19911124
8. The hypermutation activity of APOBEC-1 was decreased to background levels by a single point APOBEC-1 mutation of P29F or E181Q, while 50% of wild-type control editing at the normal site was retained. PMID: 20348446
9. The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation. PMID: 19932086
10. expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing PMID: 11815617
11. determination of multifunctional cycle and suppression of nonsense-mediated decay PMID: 12881431
12. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling PMID: 12896982
13. apobec-1-mediated apoB mRNA editing is regulated by BAG-4 PMID: 14559896
14. Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48. PMID: 15979078
15. APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase PMID: 16999936
16. No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected. PMID: 17696929
17. Demonstrates the presence of a 36-aa peptide (isoform 2) derived from this gene in adult small intestinal villi using immunocytochemical analysis. PMID: 9186903

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HGNC: 604

OMIM: 600130

KEGG: hsa:339

STRING: 9606.ENSP00000229304

UniGene: Hs.560