APOE Antibody, Biotin conjugated

Datasheet
Code CSB-PA07599D0Rb
Size US$299
Uniprot No. P02649
Protocols ELISA Protocol
Immunogen Recombinant Human Apolipoprotein E protein (21-110AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Apolipoprotein E (Apo-E), APOE
Immunogen Species Homo sapiens (Human)
Research Area Neuroscience
Target Names APOE
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Involvement in disease Hyperlipoproteinemia 3 (HLPP3); Alzheimer disease 2 (AD2); Sea-blue histiocyte disease (SBHD); Lipoprotein glomerulopathy (LPG); Familial hypercholesterolemia (FH)
Subcellular Location Secreted
Protein Families Apolipoprotein A1/A4/E family
Tissue Specificity Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, a
Database Links

HGNC: 613

OMIM: 104310

KEGG: hsa:348

STRING: 9606.ENSP00000252486

UniGene: Hs.654439

Pathway Cholesterol metabolism

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