APOE Antibody

Datasheet
Code CSB-PA227407
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P02649
Image
  • Western blot analysis of extracts from K562 cells, using APOE antibody.
Immunogen Synthesized peptide derived from C-terminal of Human APOE.
Raised in Rabbit
Species Reactivity Human
Specificity The antibody detects endogenous levels of total APOE protein.
Tested Applications ELISA,WB;WB:1:500-1:3000
Relevance Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Zannis V.I., J. Biol. Chem. 259:5495-5499(1984).
McLean J.W., J. Biol. Chem. 259:6498-6504(1984).
Paik Y.-K., Proc. Natl. Acad. Sci. U.S.A. 82:3445-3449(1985).
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias AD2; Apo-E; APOE; Apolipoprotein E; apolipoprotein E3
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names APOE
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Involvement in disease Hyperlipoproteinemia 3 (HLPP3); Alzheimer disease 2 (AD2); Sea-blue histiocyte disease (SBHD); Lipoprotein glomerulopathy (LPG); Familial hypercholesterolemia (FH)
Subcellular Location Secreted
Protein Families Apolipoprotein A1/A4/E family
Tissue Specificity Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, a
Database Links

HGNC: 613

OMIM: 104310

KEGG: hsa:348

STRING: 9606.ENSP00000252486

UniGene: Hs.654439

Pathway Cholesterol metabolism

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