COG7 Antibody

Code CSB-PA005711ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA005711ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005711ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) COG7 Polyclonal antibody
Uniprot No.
Target Names
COG7
Alternative Names
CDG2E antibody; COG complex subunit 7 antibody; cog7 antibody; COG7_HUMAN antibody; Component of oligomeric Golgi complex 7 antibody; Conserved oligomeric Golgi complex component 7 antibody; Conserved oligomeric Golgi complex subunit 7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Conserved oligomeric Golgi complex subunit 7 protein (511-770AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Required for normal Golgi function.
Gene References into Functions
  1. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. PMID: 25331899
  2. COG5- and COG7 subunits play distinctive roles in controlling Golgi structure and function PMID: 16051600
  3. Retrograde transport of multiple Golgi proteins to the ER in COG-7-deficient patient fibroblasts via brefeldin A-induced tubules was significantly slower than occurs in normal fibroblasts. PMID: 16510524
  4. A homozygous, intronic splice site mutation (c.169+4A>C) of the COG7 gene was identified in 3 patients with Congenital Disorder of Glycosylation type IIe. PMID: 17356545
  5. A new mutation in COG7 extends the spectrum of COG subunit deficiencies. PMID: 19577670

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Involvement in disease
Congenital disorder of glycosylation 2E (CDG2E)
Subcellular Location
Golgi apparatus membrane; Peripheral membrane protein.
Protein Families
COG7 family
Database Links

HGNC: 18622

OMIM: 606978

KEGG: hsa:91949

STRING: 9606.ENSP00000305442

UniGene: Hs.185807

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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