CST6 Antibody

1. High CST6 expression is associated with lymph-node metastasis in Triple-Negative Breast Cancer. PMID: 29530995
2. Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB. PMID: 27090639
3. Low CST6 expression is associated with breast cancer. PMID: 24742492
4. Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs. PMID: 23088560
5. The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals. PMID: 23006792
6. Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain activity. PMID: 22902879
7. The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival. PMID: 22688893
8. An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor, progesterone receptor, and HER4 in tumor tissues was found PMID: 21092257
9. the level of cystatin E/M regulates legumain activity and hence the invasive potential of human melanoma cells PMID: 20074384
10. CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis PMID: 12839564
11. Cystatin M suppresses the malignant phenotype of MDA-MB-435S cells. PMID: 14676833
12. Complete loss of expression of cystatin M was observed in two of three stage IV breast cancer patients. Immunohistochemical studies confirmed that expression of cystatin M in IDCs was partially or completely lost. PMID: 15466187
13. This study thus provides the first evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression. PMID: 16356477
14. Identification of CTSV & CTSL as targets for cystatin M/E, their (co)-expression in the stratum granulosum of skin, and activity of CTSL toward transglutaminase 3 strongly imply an important role for them in the differentiation process of human epidermis. PMID: 16565075
15. Tumors displaying CST6 gene methylation, display methylation in both ductal carcinoma in situ and invasive breast carcinoma lesions and reduced expression of cystatin M in these tumors was confirmed by immunohistochemistry PMID: 16912163
16. strong link between CST6 promoter hypermethylation and loss of CST6 expression in breast cancer cell lines PMID: 17043665
17. Cystatin M may encode a novel epigenetically inactivated candidate tumor suppressor gene. PMID: 17099723
18. Methylation-dependent epigenetic silencing of CST6 represents an important mechanism for loss of CST6 during breast tumorigenesis and/or progression to metastasis. PMID: 17540367
19. cystatin E/M is a cervical cancer suppressor gene and that the gene is inactivated by somatic mutations and promoter hypermethylation. PMID: 18506750
20. results demonstrate that epigenetic silencing of CST6 is frequent in adult and pediatric brain tumors and occurs in TICs, which are thought to give rise to the tumor PMID: 18607344
21. CST6, CXCL14, DHRS3, and SPP1 are regulated by BRAF signaling and may play a role in papillary thyroid carcinoma pathogenesis PMID: 18676742
22. These findings imply that CST6 is likely to involve in the proliferation and survival of pancreatic cancer probably through its proteinase inhibitory activity, and it is a promising molecular target for development of new therapeutic strategies for PDAC PMID: 18754876
23. The cysteine protease inhibitor cystatin M/E is a key regulator of a biochemical pathway that leads to epidermal terminal differentiation. PMID: 19005484
24. Cystatin M (CST6) tumor suppressor gene is concurrently down-regulated with other loci in breast epithelial cells cocultured with cancer-associated fibroblasts. PMID: 19074894
25. cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review] PMID: 19262604
26. Results suggest that the downregulation of the CST6 gene is associated with promoter histone modifications and that this association plays an important role in prostate cancer progression during the invasive and metastatic stages of the disease. PMID: 19503093
27. Methylation of cystatin M promoter is associated with breast cancer. PMID: 19551853

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HGNC: 2478

OMIM: 601891

KEGG: hsa:1474

STRING: 9606.ENSP00000311313

UniGene: Hs.139389