DNAJB9 Antibody

Datasheet

Code	CSB-PA866205ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA866205ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA866205ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DNAJB9 Polyclonal antibody

Uniprot No.

Q9UBS3

Target Names

DNAJB9

Alternative Names

DKFZP564F1862 antibody; DnaJ (Hsp40) homolog subfamily B member 9 antibody; DnaJ homolog subfamily B member 9 antibody; DNAJB9 antibody; DNJB9_HUMAN antibody; eEndoplasmic reticulum DNA J domain containing protein 4 antibody; Endoplasmic reticulum DnaJ homolog 4 antibody; ER resident protein ERdj4 antibody; ERdj4 antibody; MDG 1 antibody; Mdg-1 antibody; MDG1 antibody; Microvascular endothelial differentiation gene 1 antibody; Microvascular endothelial differentiation gene 1 protein antibody; MST049 antibody; MSTP049 antibody; OTTHUMP00000206840 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DnaJ homolog subfamily B member 9 protein (24-223AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.

Gene References into Functions

Study reports that the endoplasmic reticulum luminal co-chaperone ERdj4/DNAJB9 is a selective IRE1 repressor that promotes a complex between the luminal Hsp70 BiP and the luminal stress-sensing domain of IRE1alpha. PMID: 29198525
these results demonstrate that DNAJB9 is a downstream target of p53 that belongs to the group of negative feedback regulators of p53. PMID: 25146923
ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity. PMID: 18400946

Subcellular Location

Endoplasmic reticulum lumen.

Tissue Specificity

Widely expressed. Expressed at highest level in the liver, placenta and kidney.

Database Links

HGNC: 6968

OMIM: 602634

KEGG: hsa:4189

STRING: 9606.ENSP00000249356

UniGene: Hs.732494

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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