EBF3 Antibody, Biotin conjugated

Code CSB-PA880977LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EBF3 Polyclonal antibody
Uniprot No.
Target Names
EBF3
Alternative Names
COE 3 antibody; COE3 antibody; COE3_HUMAN antibody; Early B cell factor 3 antibody; Early B-cell factor 3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; O/E 2 antibody; O/E-2 antibody; O/E2 antibody; OE 2 antibody; OE-2 antibody; OE2 antibody; Olf 1/EBF like 2 antibody; Olf-1/EBF-like 2 antibody; Transcription factor COE3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription factor COE3 protein (416-530AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
Gene References into Functions
  1. Data show that early B-cell factor 3 (EBF3) was identified as the direct downstream target gene of miR-23b-3p. PMID: 29750239
  2. Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients. PMID: 29913442
  3. Results found that hypermethylation of the EBF3 promoter was associated with increased EBF3 mRNA levels in metastatic melanomas and subsequent inhibition of DNA methylation reduced EBF3 expression, suggesting that EBF3 promoter hypermethylation may be a candidate epigenetic driver of metastasis. PMID: 28030832
  4. In 11 affected individuals from 11 unrelated families, we identified de novo variants in EBF3 as potentially causative for the neurodevelopmental phenotype. The variants include one nonsense, two frameshift deletions, one splice, and three missense variants. There are three de novo missense variants, (p.(Lys64Thr), p.(His157Gln), and p.(Arg209Gln), which are all in the COE1 DNA-binding domain. PMID: 29162653
  5. EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation PMID: 28017370
  6. findings indicate that mutations in EBF3 cause a genetic neurodevelopmental syndrome and suggest that loss of EBF3 function might mediate a subset of neurologic phenotypes shared by ARX-related disorders, including intellectual disability, abnormal genitalia, and structural CNS malformations PMID: 28017372
  7. findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation cause intellectual disability and developmental delay and are present in approximately 0.1% of individuals with unexplained neurodevelopmental disorders PMID: 28017373
  8. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia PMID: 25609158
  9. EBF3 tumor suppressor is epigenetically silenced and that it serves as an independent prognostic marker in gastric carcinoma. PMID: 21387304
  10. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
  11. Findings suggested that the transfection of EBF3 gene into HepG2 induced the cell proliferation from G1 phase to G2 phase by increasing the number of cells. PMID: 18845077
  12. Expression of EBF3 resulted in cell cycle arrest and apoptosis. EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. PMID: 17018599
  13. Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

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Involvement in disease
Hypotonia, ataxia, and delayed development syndrome (HADDS)
Subcellular Location
Nucleus.
Protein Families
COE family
Tissue Specificity
Expressed in brain.
Database Links

HGNC: 19087

OMIM: 607407

KEGG: hsa:253738

UniGene: Hs.591374

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