FPR3 Antibody

Code CSB-PA008856LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008856LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008856LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA008856LA01HU at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FPR3 Polyclonal antibody
Uniprot No.
Target Names
FPR3
Alternative Names
FPR3; FPRH1; FPRL2; N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human N-formyl peptide receptor 3 protein (307-353AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FPR3 Antibody (Product code: CSB-PA008856LA01HU) is Non-conjugated. For FPR3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA008856LB01HU FPR3 Antibody, HRP conjugated ELISA
FITC CSB-PA008856LC01HU FPR3 Antibody, FITC conjugated
Biotin CSB-PA008856LD01HU FPR3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin.
Gene References into Functions
  1. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis. PMID: 23746112
  2. transcriptional variations of FPR3 occur by an alternative promoter during primate evolution. PMID: 21717223
  3. F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils PMID: 21709160
  4. Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. PMID: 20972812
  5. Human dendritic cells express functional FPRL2 throughout maturation. FPRL2 & its endogenous ligand may be involved in regulating DC trafficking during Ag uptake & processing s well as the T-cell-stimulating phase of the immune responses. PMID: 12223529
  6. Activation of FPRL2 inhibits lipopolysaccharide-induced dendritic cell maturation. PMID: 16002663
  7. However, F2L inhibits formyl peptide receptor (FPR) and FPRL1 activities, resulting in the inhibition of intracellular calcium increases, and superoxide generation induced by N-formyl-Met-Leu-Phe, MMK-1, or Trp-Lys-Tyr-Met-Val-d-Met in neutrophils. PMID: 17577578
  8. FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro in different conditions PMID: 19342677
  9. Human monocytes express FPR1, FPR2, and FPR3; human neutrophils express FPR1 and FPR2, but not FPR3. PMID: 19843937

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Detected in various tissues with highest expression in lung.
Database Links

HGNC: 3828

OMIM: 136539

KEGG: hsa:2359

STRING: 9606.ENSP00000341821

UniGene: Hs.445466

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