KIF1B Antibody

Code CSB-PA012319ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA012319ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA012319ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KIF1B Polyclonal antibody
Uniprot No.
Target Names
KIF1B
Alternative Names
KIF1B antibody; KIAA0591 antibody; KIAA1448Kinesin-like protein KIF1B antibody; Klp antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Kinesin-like protein KIF1B protein (1547-1816AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.; Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.
Gene References into Functions
  1. In conclusion, using a panel including 17 susceptibility genes, we documented the presence of somatic mutations in over 50% of pheochromocytomas and paragangliomas (PPGL). We confirmed the high frequency of NF1 somatic mutations and identified KIF1B as the second most frequently mutated gene in PPGL tissues. PMID: 28515046
  2. The rs17401966 polymorphism reduced the risk for HCC under the allele, heterozygous, homozygous, and dominant models but not under the additive or recessive models. PMID: 28427253
  3. BORC and Arl8 function upstream of two structurally distinct kinesin types: kinesin-1 (KIF5B) and kinesin-3 (KIF1Bbeta and KIF1A). PMID: 27851960
  4. The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of hepatocellular carcinoma in Chinese individuals. PMID: 27122668
  5. Increased KIF1B was associated with worse WHO pathological classification, Karnofsky performance status, and prognosis. Silencing KIF1B inhibited expression of membranal MT1-MMP. PMID: 26576027
  6. Downregulation of KIF1B in hepatocellular carcinoma tissues is associated with poor prognosis. PMID: 26217094
  7. the rs17401966 polymorphism likely regulates KIF1B mRNA expression and thus may be associated with epithelial ovarian cancer risk in Eastern Chinese women. PMID: 25854172
  8. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
  9. Results from targeted sequencing in patients with acute lymphoblastic leukemia identified KMT2D and KIF1B as novel putative driver genes and a putative regulatory non-coding variant that coincided with overexpression of the growth factor MDK. PMID: 25355294
  10. The variant G allele of rs17401966 may be a favorable biomarker for the prognosis of intermediate or advanced hepatitis B virus-related hepatocellular carcinoma patients in this Chinese population PMID: 25153661
  11. the KIF1B gene SNP (rs174019660) showed no significant association with HBV-related hepatocellular carcinoma in Thai patients infected with HBV, indicating that there must be other mechanisms or pathways involved in hepatocellular carcinoma. PMID: 23803045
  12. The meta-analysis showed a significant association between kinesin family member 1B (KIF1B) single nucleotide polymorphism (rs17401966) and hepatocellular carcinoma (HCC). PMID: 24952890
  13. Results show that KIF1Bbeta has neuroblastoma tumor-suppressor properties and promotes and requires nuclear-localized DHX9 for its apoptotic function by activating XAF1 expression. PMID: 24469107
  14. KIF1B may play a critical role in the development of hepatocellular carcinoma PMID: 23634229
  15. Leptin, MT1-MMP and KIF1B are overexpressed in GC tissues. PMID: 23354307
  16. the TT genotype of rs1535045 was associated with a slower progression of MS and early MS onset. PMID: 23528589
  17. activity-dependent synaptic recruitment of KIF1Bbeta, its interaction with Ca(2 ) sensor Calmodulin and its role as a dendritic motor of ribonucleoprotein complexes provide a novel basis for understanding the coordination of motor protein mobilization and synaptic signaling pathways PMID: 22945799
  18. Polymorphisms at KIF1B gene locus investigated in this study showed no significant association with Hepatitis B virus infection. PMID: 23028799
  19. This study showed the new locus identified for hepatocellular carcinoma, KIF1B, was not associated with progression to chronic hepatitis B. PMID: 22363396
  20. No association is found between rs10492972 KIF1B polymorphism and the progression of multiple sclerosis in Greek subjects. PMID: 21424745
  21. Polymorphic locus rs10492972 of the KIF1B gene associates with multiple sclerosis in Russia. PMID: 21680216
  22. analysis of the KIF1B rs10492972*C allelic association in multiple sclerosis PMID: 21594895
  23. Data show that no evidence could be found for a determining influence of carriership of the risk allele or genotype of the KIF1B gene on any of the multiple sclerosis neurodegenerative phenotypic markers studied. PMID: 21606458
  24. KIF1B rs10492972 allelic variant does not act as a risk factor as well as a disease modifier in a Italian cohort of patients with progressive relapsing multiple sclerosis. PMID: 20067515
  25. Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. PMID: 20190806
  26. KIF1Ba in addition to KIF1Bbeta may not be a candidate tumor suppressor gene for neuroblastoma PMID: 12888911
  27. KBP is a new binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a new type of kinesin interacting protein. PMID: 16225668
  28. We detected ALS-specific down-regulation of KIF1Bbeta and novel KIF3Abeta, two isoforms we show to be enriched in the brain, and also of SOD1, a key enzyme linked to familial ALS. PMID: 17418584
  29. Study identified inherited loss-of-function KIF1Bbeta missense mutations in neuroblastomas and pheochromocytomas and an acquired loss-of-function mutation in a medulloblastoma. PMID: 18334619
  30. KIF1Bbeta may act as a haploinsufficient tumor suppressor, and its allelic loss may be involved in the pathogenesis of neuroblastoma and other cancers. PMID: 18614535
  31. a germline mutation in the KIF1B beta gene on 1p36 may have a role in neural and nonneural tumors PMID: 18726616
  32. Study reports a genome wide association study identifying a new locus replicated in 2,679 cases and 3,125 controls; an rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). PMID: 18997785

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Involvement in disease
Charcot-Marie-Tooth disease 2A1 (CMT2A1); Neuroblastoma 1 (NBLST1); Pheochromocytoma (PCC)
Subcellular Location
Cytoplasm, cytoskeleton. Mitochondrion. Cell projection, axon.; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily
Tissue Specificity
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney,
Database Links

HGNC: 16636

OMIM: 118210

KEGG: hsa:23095

STRING: 9606.ENSP00000263934

UniGene: Hs.97858

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