MIEN1 Antibody

1. these results suggest the MIEN1 promoter has a short interspersed nuclear Alu element region that is hypermethylated in normal cells leading to repression of the gene; in cancer, the hypomethylation of a part of this repeat, in addition to the binding of USF, results in MIEN1 expression PMID: 27589566
2. Data show that migration and invasion enhancer 1 (MIEN1) plays an essential role in maintaining the plasticity of the dynamic membrane-associated actin cytoskeleton, which leads to an increase in cell motility, suggesting targeting MIEN1 might represent a promising means to prevent breast tumor metastasis. PMID: 27462783
3. Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells. PMID: 28859163
4. indicate that MIEN1 overexpression may facilitate migration and invasion in breast cancer PMID: 28198505
5. In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment. PMID: 26827826
6. MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. PMID: 26272794
7. MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells. PMID: 25996585
8. C35 might serve as a biomarker or therapeutic target for management of colorectal cancer. PMID: 26173296
9. While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. PMID: 25406943
10. results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells. PMID: 23880825
11. Results suggest that MIEN1 may have an important regulatory role in phosphorylation of AKT with its redox potential. PMID: 23284973
12. prenylation is required for the function of the C17orf37 protein in cancer cells PMID: 21628459
13. Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells. PMID: 21068479
14. Data strongly suggest C17orf37 overexpression in prostate cancer functionally enhances migration and invasion of tumor cells, and is an important target for cancer therapy. PMID: 19503095
15. MGC14832 gene is located within human chromosome 17q12 amplicon, including PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes. PPP1R1B ~ ERBB2 ~ GRB7 locus is amplified in human gastric cancer and breast cancer. PMID: 12739007

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HGNC: 28230

OMIM: 611802

KEGG: hsa:84299

STRING: 9606.ENSP00000377778

UniGene: Hs.333526