MXD4 Antibody

Datasheet

Code	CSB-PA257244
Size	US$297
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Image	Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MAD4 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MXD4 Polyclonal antibody

Uniprot No.

Q14582

Target Names

MXD4

Alternative Names

bHLHc12 antibody; Class C basic helix loop helix protein 12 antibody; Class C basic helix-loop-helix protein 12 antibody; MAD 4 antibody; MAD4 antibody; Mad4 homolog antibody; MAD4_HUMAN antibody; Max associated protein 4 antibody; MAX dimerization protein 4 antibody; Max dimerizer 4 antibody; Max interacting transcriptional repressor MAD4 antibody; Max-associated protein 4 antibody; Max-interacting transcriptional repressor MAD4 antibody; MST 149 antibody; MST149 antibody; MSTP 149 antibody; MSTP149 antibody; MXD 4 antibody; MXD4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human MAD4.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.

Gene References into Functions

The E3 ligase activity of c-IAP1 was not required for downregulation of Mad4 expression. PMID: 22895069
regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc PMID: 12418961
Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes PMID: 16167342

Subcellular Location

Nucleus.

Database Links

HGNC: 13906

KEGG: hsa:10608

STRING: 9606.ENSP00000337889

UniGene: Hs.655020

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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