NPAS4 Antibody, HRP conjugated

Code CSB-PA814204LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) NPAS4 Polyclonal antibody
Uniprot No. Q8IUM7
Target Names NPAS4
Alternative Names bHLH PAS type transcription factor NXF antibody; bHLHe79 antibody; Class E basic helix-loop-helix protein 79 antibody; HLH-PAS transcription factor NXF antibody; Le PAS antibody; limbic enhanced PAS protein antibody; neuronal PAS domain protein 4 antibody; Neuronal PAS domain-containing protein 4 antibody; Neuronal PAS4 antibody; NPAS4 antibody; NPAS4_HUMAN antibody; NXF antibody; PAS domain-containing protein 10 antibody; PASD10 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Neuronal PAS domain-containing protein 4 protein (445-585AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1
Gene References into Functions
  1. NPAS4 is expressed in endothelial cells, regulates VE-cadherin expression and regulates sprouting angiogenesis. PMID: 28082451
  2. This review summarizes the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. [review] PMID: 26690124
  3. we provide the first evidence that Npas4 is expressed during embryonic development and that it may have a developmental role that is unrelated to its function in the adult brain PMID: 24887558
  4. These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation. PMID: 24465693
  5. a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome PMID: 14701734

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Subcellular Location Nucleus
Tissue Specificity Brain.
Database Links

HGNC: 18983

OMIM: 608554

KEGG: hsa:266743

STRING: 9606.ENSP00000311196

UniGene: Hs.256036

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