OSTF1 Antibody

Code CSB-PA017266GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
bA235O14.1 antibody; FLJ20559 antibody; OSF antibody; Osteoclast stimulating factor 1 antibody; Osteoclast-stimulating factor 1 antibody; Ostf1 antibody; OSTF1_HUMAN antibody; SH3P2 antibody
Raised in
Species Reactivity
Human OSTF1
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Gene References into Functions
  1. Data show that SH3P2 was phosphorylated on Ser(202) by ribosomal S6 kinase (RSK) in an ERK pathway-dependent manner, and such phosphorylation inhibited the ability of SH3P2 to suppress cell motility. PMID: 21501342
  2. SH3P2, a novel component of adhesion sites, is involved in Cbl and Src-mediated pathways PMID: 15135048
  3. Crystals of human osteoclast-stimulating factor were obtained by the hanging-drop vapour-diffusion method using X ray crystallography. PMID: 16508112
  4. The SH3 domain structure of osteoclast stimulating factor at atomic resolution provides an accurate framework for structure-based design of its inhibitors. PMID: 16946461
  5. The peptide-binding groove of OSTF-SH3 domain adopts a conformation different from other SH3 domains and probably needs a conformational switch for binding to its proline-rich ligand; this status is possibly regulated by the C-terminal ankyrin repeats. PMID: 19137598

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Subcellular Location
Tissue Specificity
Ubiquitously expressed. Present in osteoclasts (at protein level).
Database Links

HGNC: 8510

OMIM: 610180

KEGG: hsa:26578

STRING: 9606.ENSP00000340836

UniGene: Hs.494192

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