PLEKHA7 Antibody, Biotin conjugated

1. Downregulation of PLEKHA7 in PACG may affect BAB integrity and aqueous humor outflow via its Rac1/Cdc42 GAP activity, thereby contributing to disease etiology. PMID: 29016860
2. our findings support a multi-layered role of PLEKHA7 in converging cytoskeletal dynamics and miRNA-mediated growth regulation at the ZA, with potentially critical implications in cancer that warrant further investigation. PMID: 26822694
3. These results show that the PLEKHA7-PDZD11 complex stabilizes nectins to promote efficient early junction assembly and uncover a new molecular mechanism through which PLEKHA7 recruits PDZ-binding membrane proteins to epithelial adherens junctions. PMID: 27044745
4. Familial linkage studies for primary angle-closure glaucoma have been performed and identified PLEKHA7 causative primary glaucoma disease PMID: 26497787
5. PLEKHA7 is a junctional marker of epithelial cells within tubular structures both in normal breast tissue and ductal carcinomas PMID: 26270346
6. PLEKHA7 localization to adherens junctions is E-cadherin and p120 dependent. PMID: 26302406
7. This meta-analysis suggests that PLEKHA7 rs11024102 is associated with PACG (primary angle closure glaucoma) in Asian population and COL11A1 rs3753841 has a genetic association with the development of PACG both in Caucasian and Asian populations. PMID: 25732101
8. PLEKHA7 recruits the microprocessor complex and its core components DROSHA and DGCR8 to the zonula adherens, to suppress growth-related signaling via miRNAs PMID: 26302406
9. Specific localization of PLEKHA7 was found within PACG-related structures (iris, ciliary body, and choroid) and blood-aqueous barrier (BAB) structures (posterior iris epithelium, nonpigmented ciliary epithelium, iris and ciliary body microvasculature). PMID: 24801512
10. Our study suggests that rs1676486 and rs12138977 in COL11A1 as well as rs216489 and rs11024102 in PLEKHA7 are associated with an increased risk of PAC/PACG in the Han Chinese population PMID: 24854855
11. Axial length, anterior chamber depth and keratometry were not associated with rs3753841 or rs11024102 genotypes including after adjusting for age and sex. PMID: 23505305
12. Overexpression of PLEKHA7 is common in in-vasive lobular carcinomas and could be a molecular marker to differentiate them from invasive ductal carcinomas. PMID: 22542108
13. Genetic variations in CYP17A1, CACNB2 and PLEKHA7 were related to blood pressure traits and/or hypertension in Chinese She population. PMID: 21963141
14. PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, distinct from ZO-1 and E-cadherin PMID: 20808826
15. PLEKHA7 binds with p120catenin and non-centrosomal minus end protein Nezha and plays a linker role between adherens junction and non-centrosomal microtubules. PMID: 19041755

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HGNC: 27049

OMIM: 612686

KEGG: hsa:144100

STRING: 9606.ENSP00000347883

UniGene: Hs.12332