POLRMT Antibody, FITC conjugated

Code CSB-PA018353LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) POLRMT Polyclonal antibody
Uniprot No. O00411
Target Names POLRMT
Alternative Names APOLMT antibody; DNA-directed RNA polymerase antibody; DNA-directed RNA polymerase mitochondrial antibody; h-mtRPOL antibody; mitochondrial antibody; MTRNAP antibody; MtRPOL antibody; POLRMT antibody; polymerase (RNA) mitochondrial (DNA directed) antibody; polymerase, RNA, mitochondrial antibody; RPOM antibody; RPOM_HUMAN antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human DNA-directed RNA polymerase, mitochondrial protein (282-405AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene References into Functions
  1. the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined. PMID: 27436287
  2. Suggest targeting POLRMT as strategy for treating acute myeloid leukemia. PMID: 26484416
  3. knock-down of MRPL12 by RNA interference results in instability of POLRMT. PMID: 26586915
  4. Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes. PMID: 26403317
  5. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
  6. The results demonstrate that human TFAM binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP. PMID: 24393772
  7. Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs. PMID: 24096365
  8. Authors propose that POLRMT interacts directly with h-mtTFB1 in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity. PMID: 23303773
  9. X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension PMID: 21947009
  10. muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII) PMID: 21799907
  11. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds PMID: 21548588
  12. POLRMT can function as an origin-specific primase in mammalian mitochondria. PMID: 20129056
  13. human mitochondrial DNA polymerase has a role in autosomal dominant progressive external ophthalmoplegia PMID: 15258572
  14. POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition PMID: 15526033
  15. transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV), expressed from an alternative transcript of the mitochondrial RNA polymerase gene POLRMT PMID: 16079853
  16. the MRPL12 interaction with POLRMT is likely part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation PMID: 17337445
  17. Promoter-independent DNA conformation-dependent transcription required TFB2M and was suppressed by TFAM, while promoter-dependent transcription was inhibited to a lesser extent BY TFAM. PMID: 19624753

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Subcellular Location Mitochondrion
Protein Families Phage and mitochondrial RNA polymerase family
Database Links

HGNC: 9200

OMIM: 601778

KEGG: hsa:5442

STRING: 9606.ENSP00000215591

UniGene: Hs.254113

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