PTPN9 Antibody, Biotin conjugated

Code CSB-PA019045LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PTPN9 Polyclonal antibody
Uniprot No.
Target Names
PTPN9
Alternative Names
MEG2 antibody; non-receptor type 9 antibody; protein tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG2 antibody; Protein-tyrosine phosphatase MEG2 antibody; PTN9_HUMAN antibody; PTPase MEG2 antibody; Ptpn9 antibody; Tyrosine protein phosphatase non receptor type 9 antibody; Tyrosine-protein phosphatase non-receptor type 9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tyrosine-protein phosphatase non-receptor type 9 protein (221-339AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.
Gene References into Functions
  1. Results from a study on gene expression variability markers in early-stage human embryos shows that PTPN9 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
  2. this study highlights an important role for miR-96 in the regulation of PTPN9 in breast cancer cells and may provide insight into the molecular mechanisms of breast carcinogenesis. PMID: 27857177
  3. Expression of MEG2 is reversely correlated with that of miR-181a-5p in gastric cancer. PMID: 28747184
  4. PTPN9 inhibited cell proliferation in HepG2 cells. PMID: 26715439
  5. PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3 and plays a critical role in breast cancer development. PMID: 22394684
  6. This study indentified VEGFR2 as a PTPN9 substrate, and indicated that PTPN9 is a negative regulator of VEGFR2 signaling and function in endothelial cells. PMID: 22763125
  7. data suggest PTPN9 as a negative regulator of breast cancer cells by targeting ErbB2 and EGFR and inhibiting STAT activation PMID: 20335174
  8. Purification and characterization of protein tyrosine phosphatase PTP-MEG2 PMID: 12112018
  9. PTP-MEG2 has an important role in the development of erythroid cells. PMID: 12920026
  10. PTPase-MEG2 through its Sec14p homology domain couples inositide phosphorylation to tyrosine dephosphorylation and the regulation of intracellular traffic of the secretory pathway in T cells. PMID: 14662869
  11. PTP-MEG2 reduced the phosphotyrosine content of NSF and co-localized with NSF and syntaxin 6 in intact cells, the first demonstrated role for a protein tyrosine phosphatase in the regulated secretory pathway PMID: 15322554
  12. role in the negative regulation of hepatic insulin signaling PMID: 16679294
  13. the N terminus of PTPMEG2 is necessary for the targeting of this phosphatase to the secretory vesicle compartment by association with other proteins involved in intracellular transport. PMID: 17387180

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Subcellular Location
Cytoplasm.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class 3 subfamily
Database Links

HGNC: 9661

OMIM: 600768

KEGG: hsa:5780

STRING: 9606.ENSP00000303554

UniGene: Hs.445775

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