RGS19 Antibody

Datasheet

Code	CSB-PA019650LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019650LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA019650LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA019650LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RGS19 Polyclonal antibody

Uniprot No.

P49795

Target Names

RGS19

Alternative Names

G alpha interacting protein antibody; G protein signalling regulator 19 antibody; G protein; alpha-interacting protein antibody; G-alpha-interacting protein antibody; GAIP antibody; GNAI3IP antibody; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody; Regulator of G protein signalling 19 antibody; Regulator of G-protein signaling 19 antibody; RGS19 antibody; RGS19_HUMAN antibody; RGSGAIP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RGS19 Antibody (Product code: CSB-PA019650LA01HU) is Non-conjugated. For RGS19 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA019650LB01HU	RGS19 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019650LC01HU	RGS19 Antibody, FITC conjugated
Biotin	CSB-PA019650LD01HU	RGS19 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Gene References into Functions

RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal. PMID: 26116529
RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect. PMID: 24793302
Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity. PMID: 23799031
The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23. PMID: 23416464
elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases PMID: 22045062
cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced PMID: 21705135
gene structure and transcription regulation PMID: 12507475
GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling PMID: 15356268

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Subcellular Location

Membrane; Lipid-anchor.

Tissue Specificity

Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Database Links

HGNC: 13735

OMIM: 605071

KEGG: hsa:10287

STRING: 9606.ENSP00000333194

UniGene: Hs.422336

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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