CNOT9 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA842140LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CNOT9 Polyclonal antibody

Uniprot No.

Q92600

Target Names

CNOT9

Alternative Names

CNOT9 antibody; RCD1 antibody; RQCD1CCR4-NOT transcription complex subunit 9 antibody; Cell differentiation protein RQCD1 homolog antibody; Rcd-1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CCR4-NOT transcription complex subunit 9 protein (1-258AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.

Gene References into Functions

Data indicate a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas. PMID: 25544760
Crystal structures of the DDX6, CNOT1 and CNOT9 complexes. PMID: 24768538
Crystal structure of the DDX6, CNOT9 and CNOT1 complex. PMID: 24768540
Our findings in this study imply the functional mechanism of RQCD1 in the Akt activity regulation as a mediator in the EGFR-signaling pathway PMID: 20878056
mammalian protein is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation PMID: 12356739
CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1 PMID: 18180299
Report involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells. PMID: 19724902

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Subcellular Location

Nucleus. Cytoplasm, P-body.

Protein Families

CNOT9 family

Tissue Specificity

Detected in spleen, thymus, prostate, testis, ovary and intestine.

Database Links

HGNC: 10445

OMIM: 612054

KEGG: hsa:9125

STRING: 9606.ENSP00000273064

UniGene: Hs.148767

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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