SCARA5 Antibody, HRP conjugated

Code CSB-PA020766LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) SCARA5 Polyclonal antibody
Uniprot No. Q6ZMJ2
Target Names SCARA5
Alternative Names FLJ23907 antibody; MGC45780 antibody; NET33 antibody; SCAR5_HUMAN antibody; SCARA 5 antibody; scara5 antibody; Scavenger receptor class A member 5 antibody; Scavenger receptor class A; member 5 (putative) antibody; Scavenger receptor class A; member 5 antibody; Scavenger receptor hlg antibody; Tesr antibody; Testis expressed scavenger receptor antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Scavenger receptor class A member 5 protein (303-428AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Gene References into Functions
  1. our data provide a novel evidence for the biological and clinical significance of SPAG5 as a potential biomarker, and we demonstrate that SPAG5-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression. PMID: 30249289
  2. SCARA5 may play an important role in tumorigenesis of breast cancer via promoter methylation PMID: 29908284
  3. The present results provide the first evidence that SCARA5 inhibits lymphangiogenesis by downregulating VEGF-C, thereby inhibiting breast cancer lymphatic metastasis. PMID: 28497372
  4. Knockdown of CSN5 increased SCARA5 expression and inhibited the proliferation and metastasis of HCC cells in vitro and in vivo. Finally, it was found that CSN5 regulated SCARA5 expression by modulating beta-catenin. PMID: 29189991
  5. The methylation status of SCARA5 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer. PMID: 29019900
  6. Taken together, these results suggest that this newly identified Rock2-beta-catenin/TCF4-SCARA5 axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC. PMID: 27793664
  7. SCARA5 and SBSN shown to have modest effects on cell proliferation or collagen gel contraction and maybe associated with peripheral vein graft patency. PMID: 25935274
  8. this study demonstrated that knockdown of SCARA5 inhibits PDGFBBinduced HASMC proliferation and migration through suppression of the PDGF signaling pathway. PMID: 27035566
  9. The overexpression of SCARA5 significantly inhibited the proliferation, colony formation and migration/invasion abilities of osteosarcoma cells. PMID: 26847210
  10. Scara5 was downregulated, pointing out this receptor as a potential player implicated in retinopathy and also as a possible therapeutic target. PMID: 25259650
  11. Results demonstrate the involvement of SCARA3 and SCARA5 in the uptake of PF14-oligonucleotide nanocomplexes. PMID: 22138034
  12. Data show that decidualization was associated with increased expression of 428 genes including SCARA5 (181-fold), DKK1 (71-fold) and PROK1 (32-fold), and decreased expression of 230 genes including MMP-7 (35-fold) and SFRP4 (21-fold). PMID: 21858178
  13. Observational study of gene-disease association. (HuGE Navigator) PMID: 21029358
  14. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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Subcellular Location Cell membrane, Single-pass type II membrane protein
Protein Families SCARA5 family
Database Links

HGNC: 28701

OMIM: 611306

KEGG: hsa:286133

STRING: 9606.ENSP00000346990

UniGene: Hs.591833

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