SDHAF2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA885749LD01HU
Size US$299
Uniprot No. Q9NX18
Protocols ELISA Protocol
Immunogen Recombinant Human Succinate dehydrogenase assembly factor 2, mitochondrial protein (30-166AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2), SDHAF2, C11orf79 PGL2 SDH5
Immunogen Species Homo sapiens (Human)
Research Area Others
Target Names SDHAF2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Involvement in disease Paragangliomas 2 (PGL2)
Subcellular Location Mitochondrion matrix
Protein Families SDHAF2 family
Database Links

HGNC: 26034

OMIM: 601650

KEGG: hsa:54949

STRING: 9606.ENSP00000301761

UniGene: Hs.313247

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