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SOSTDC1 Antibody

Datasheet
Code CSB-PA022416EA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SOSTDC1 Polyclonal antibody
Uniprot No.
Q6X4U4
Target Names
SOSTDC1
Alternative Names
CDA019 antibody; DKFZp564D206 antibody; Ectodermal BMP inhibitor antibody; Ectodin antibody; sclerostin domain containing 1 antibody; Sclerostin domain containing protein 1 antibody; Sclerostin domain-containing protein 1 antibody; SOSD1_HUMAN antibody; Sostdc1 antibody; USAG-1 antibody; USAG1 antibody; Uterine sensitization associated gene 1 protein antibody; Uterine sensitization-associated gene 1 protein antibody; Wise antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sclerostin domain-containing protein 1 protein (24-206AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SOSTDC1 Antibody (Product code: CSB-PA022416EA01HU) is Non-conjugated. For SOSTDC1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA022416EB01HU SOSTDC1 Antibody, HRP conjugated ELISA
FITC CSB-PA022416EC01HU SOSTDC1 Antibody, FITC conjugated
Biotin CSB-PA022416ED01HU SOSTDC1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SOSTDC1 Antibodies

SOSTDC1 Proteins

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Target Background

Function
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
Gene References into Functions
  1. findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. PMID: 28551845
  2. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. PMID: 26378658
  3. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
  4. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer PMID: 25858146
  5. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1. PMID: 24190897
  6. DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer. PMID: 23830730
  7. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer. PMID: 21113658
  8. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women. PMID: 21221677
  9. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors. PMID: 21080955
  10. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
  11. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist. PMID: 15020244
  12. This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors. PMID: 18032587
  13. Loss of SOSTDC1 gene is associated with Wilms tumor. PMID: 19760604

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Subcellular Location
Secreted.
Protein Families
Sclerostin family
Tissue Specificity
Highly expressed in kidney and weakly in lung.
Database Links

HGNC: 21748

OMIM: 609675

KEGG: hsa:25928

STRING: 9606.ENSP00000304930

UniGene: Hs.648106

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