STK25 Antibody

Datasheet

Code	CSB-PA022842LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA022842LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022842LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STK25 Polyclonal antibody

Uniprot No.

O00506

Target Names

STK25

Alternative Names

C86992 antibody; Serine/threonine kinase 25 antibody; Serine/threonine kinase 25 (STE20 homolog, yeast) antibody; Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a antibody; Serine/threonine kinase 25 (yeast) antibody; Serine/threonine protein kinase 25 antibody; Serine/threonine-protein kinase 25 antibody; SOK 1 antibody; SOK-1 antibody; SOK1 antibody; Ste20 like kinase antibody; Ste20 yeast homolog antibody; Ste20-like antibody; STE20-like kinase antibody; Ste20/oxidant stress response kinase 1 antibody; Sterile 20 (oxidant stress response kinase 1) antibody; Sterile 20/oxidant stress-response kinase 1 antibody; STK25 antibody; STK25_HUMAN antibody; Yeast Sps1/Ste20 related kinase 1 antibody; YSK 1 antibody; YSK1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Serine/threonine-protein kinase 25 protein (1-426AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The STK25 Antibody (Product code: CSB-PA022842LA01HU) is Non-conjugated. For STK25 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA022842LB01HU	STK25 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022842LC01HU	STK25 Antibody, FITC conjugated
Biotin	CSB-PA022842LD01HU	STK25 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Gene References into Functions

STK25 regulates lipid partitioning in human liver cells by controlling TAG synthesis as well as lipolytic activity and thereby NEFA release from lipid droplets for beta-oxidation and TAG secretion. PMID: 26553096
Our results suggest that MST4, STK25 and PDCD10 are upregulated in prostate cancer and may play roles in prostate tumorigenesis. PMID: 25550858
This review notes that all 3 human germinal center kinase III genes consist of 12 exons and are ubiquitously expressed. In SOK1 and MST4, exon 1 encodes a 5' untranslated region, but this is not the case for MST3. PMID: 23889253
Down-modulation of STK25, but not STK24, rescued medulloblastoma cells from NGF-induced TrkA-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA and CCM2. PMID: 22782892
PDCD10 might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression. PMID: 22652780
Significantly higher STK25 levels were observed in the skeletal muscle of type 2 diabetic patients, compared with individuals with normal glucose tolerance. PMID: 22391949
The results of the study results indicate that attenuation of SOK1 enhanced cell migration and lead to changes in the expression of migration-associated proteins such as FAK and GM130. PMID: 21396913
In cultured human endothelial cells, CCM3 and STK25 regulated barrier function in a manner similar to CCM2, and STKs negatively regulated Rho by directly activating moesin. PMID: 20592472
14-3-3zeta is a specific substrate for YSK1 that localizes to the Golgi apparatus, and potentially links YSK1 signaling at the Golgi apparatus with protein transport. PMID: 15037601
Ste20 family member (MAP4K3) that is required for maximal S6K (S6 kinase)/4E-BP1 [eIF4E (eukaryotic initiation factor 4E) that is required for maximal S6K (S6 kinase). PMID: 17253963
SOK1 entry into the nucleus is important for the cell death response PMID: 18364353

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Subcellular Location

Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus.

Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Tissue Specificity

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Database Links

HGNC: 11404

OMIM: 602255

KEGG: hsa:10494

STRING: 9606.ENSP00000325748

UniGene: Hs.516807

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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