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SUPT4H1 Antibody

Datasheet
Code CSB-PA022957ESR1HU
Size US$166
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Image
  • Immunohistochemistry(IHC) 1- SUPT4H1 Antibody

    Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022957ESR1HU at dilution of 1:100

  • Immunohistochemistry(IHC) 2- SUPT4H1 Antibody

    Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022957ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SUPT4H1 Polyclonal antibody
Uniprot No.
P63272
Target Names
SUPT4H1
Alternative Names
DRB sensitivity-inducing factor 14 kDa subunit antibody; DRB sensitivity-inducing factor small subunit antibody; DSIF p14 antibody; DSIF small subunit antibody; hSPT4 antibody; SPT4 antibody; SPT4H antibody; SPT4H_HUMAN antibody; SUPT4H `1 antibody; SUPT4H antibody; Supt4h1 antibody; Transcription elongation factor spt4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription elongation factor SPT4 protein (1-117AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SUPT4H1 Antibodies

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Target Background

Function
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Gene References into Functions
  1. Chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. PMID: 27461012
  2. Knockdown of SUPT4H1, the human Spt4 ortholog, similarly decreased production of sense and antisense RNA foci, as well as dipeptide repeat proteins, in patient cells. PMID: 27516603
  3. crystal structure of hSpt4 in complex with the dimerization region of hSpt5 PMID: 19860741
  4. Upon induction of NF-kappaB, a subset of target genes is regulated differentially by either P-TEFb or DSIF.[P-TEFb, DSIF] PMID: 17502349
  5. These findings reveal a dynamic regulation of DSIF involving either E-box or NF-kappaB depending on the physiological circumstances. PMID: 17962196
  6. Spt4 was purified and characterized. PMID: 18373978
  7. These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II. PMID: 19210550
  8. he Paf1 complex (Paf1C) and Tat-SF1, two factors implicated previously in elongation control, collaborate with DSIF to facilitate efficient elongation PMID: 19952111

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Subcellular Location
Nucleus.
Protein Families
SPT4 family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 11467

OMIM: 603555

KEGG: hsa:6827

STRING: 9606.ENSP00000225504

UniGene: Hs.439481

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