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SVBP Antibody, FITC conjugated

Datasheet
Code CSB-PA836653LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SVBP Polyclonal antibody
Uniprot No.
Q8N300
Target Names
SVBP
Alternative Names
SVBP antibody; CCDC23 antibody; Small vasohibin-binding protein antibody; Coiled coil domain-containing protein 23 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Small vasohibin-binding protein (1-66AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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SVBP Antibodies

SVBP Proteins

Customer Reviews and Q&A

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Target Background

Function
Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation.
Gene References into Functions
  1. identified a novel UPS regulatory system in which essential domain architecture (VASH-PS) of VASHs, comprising regions VASH191-180 and VASH280-169 , regulate the cytosolic punctate structure formation in the absence of SVBP. PMID: 27879017
  2. VASH2 contributes to the angiogenesis in hepatocellular carcinoma via an SVBP-mediated paracrine mechanism. PMID: 22614011
  3. SVBP(CCDC23)acts as a secretory chaperone for VASH1. PMID: 20736312
Subcellular Location
Cytoplasm. Secreted. Cytoplasm, cytoskeleton.
Protein Families
SVBP family
Database Links

HGNC: 29204

OMIM: 617853

KEGG: hsa:374969

STRING: 9606.ENSP00000361599

UniGene: Hs.113919

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