TMEM132D Antibody, FITC conjugated

Code CSB-PA023702LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TMEM132D Polyclonal antibody
Uniprot No.
Target Names
TMEM132D
Alternative Names
TMEM132D antibody; HBE120 antibody; KIAA1944 antibody; MOLT antibody; Transmembrane protein 132D antibody; Mature oligodendrocytes transmembrane protein antibody; Mature OL transmembrane protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transmembrane protein 132D protein (796-909AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May serve as a cell-surface marker for oligodendrocyte differentiation.
Gene References into Functions
  1. Thus, GPC6 and TMEM132D may serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis. PMID: 26448945
  2. TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotionl signals PMID: 25974322
  3. Enhanced amygdala gray matter volumes and anxiety-related (but not panic-specific) personality profiles are found in healthy normal carriers of the rs11060369 AA TMEM132D genotype. PMID: 24495968
  4. data suggest that not only common but also putatively functional and/or rare variants within TMEM132D might contribute to the risk to develop anxiety disorders PMID: 22911938
  5. TMEM132D was first identified as a possible candidate gene for panic disorder in a genome-wide association study conducted at the Max Planck Institute of Psychiatry in Munich. PMID: 22948381
  6. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. PMID: 21784300
  7. TMEM132D may be an important new candidate gene for PD as well as more generally for anxiety-related behavior. PMID: 20368705

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
TMEM132 family
Tissue Specificity
Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.
Database Links

HGNC: 29411

OMIM: 611257

KEGG: hsa:121256

STRING: 9606.ENSP00000408581

UniGene: Hs.507268

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