TP53INP2 Antibody

1. TP53INP2 promotes ribosome biogenesis through facilitating rRNA synthesis at the nucleolus PMID: 27172002
2. We conducted a replication study using a dataset outside of the Challenge, and found the association between TP53INP2 and ER-negative breast cancer was significant (p = 5.07x10-3). Expression of HP (16q22.2) showed a suggestive association with ER-negative breast cancer in the discovery phase (Z = 4.30, p = 1.70x10-5) although the association was not significant after Bonferroni adjustment. PMID: 28957356
3. The results reveal the association of TP53INP2-related basal autophagy with cell growth and malignant progression of human liposarcoma. PMID: 28131096
4. nucleolus integrity is not essential for both DOR nucleo-cytoplasmic shuttling and DOR function on basal autophagy PMID: 22750142
5. Mutation of conserved hydrophobic residues in region 1 of TP53inp2 reduces transcriptional activity, and blocks nuclear exit and autophagic activity under autophagy-activated conditions. PMID: 22470510
6. DOR plays an important role in thyroid hormone-mediated osteoblast differentiation, and a DOR SNP associates with plasma osteocalcin in men. PMID: 21467300
7. TP53INP2 is a novel gene involved in the autophagy of mammalian cells. PMID: 19056683
8. Alternative splicing of an exon in the 5' untranslated region of a gene termed TP53INP2 is a key event downstream of hnRNP A2 that is necessary for cells to invade the extracellular matrix. PMID: 19934309

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HGNC: 16104

OMIM: 617549

KEGG: hsa:58476

STRING: 9606.ENSP00000363942

UniGene: Hs.516994