Recombinant Arabidopsis thaliana Auxin efflux carrier component 2 (PIN2), partial

1. Mutation in PIN2 conservative cysteine domain leads to increased intracellular accumulation and altered protein distribution within plasma membrane micro-domains. PMID: 29109378
2. The results suggest a peroxisomal ROS-based auxin signaling pathway involving spatiotemporal-dependent CuAOzeta functional regulation of PIN2 homeostasis, auxin distribution, and LR development. PMID: 28992128
3. Data indicate that neither the naturally occurring auxins indole-3-acetic acid and indole-3-butyric acid, nor the synthetic auxin analogs were able to inhibit endocytosis of the putative auxin transporter PIN-FORMED2 (PIN2) in root epidermis cells. PMID: 27506239
4. Brief treatment with indole-3-carbinol led to a reduction in the amount of PIN1 and to mislocalization of PIN2. PMID: 26252364
5. PIN2 auxin efflux carriers are differentially controlled in tricho- and atrichoblast cells. PIN2 proteins show lower abundance at the plasma membrane of trichoblast cells, despite showing higher rates of intracellular trafficking in these cells. PMID: 26041320
6. under low-B conditions PIN1 is down-regulated and PIN2 plays an important role in root meristem maintenance. PMID: 25814435
7. Reduction in PIN2 intensity, polarization, and endocytosis under low phosphate conditions is MAX2 dependent. PMID: 25609825
8. Functional interplay between protein kinase CK2 and salicylic acid sustains PIN2 transcriptional expression. PMID: 24547808
9. By using solubilized membrane protein immunoprecipitation assays, we established quantitative approaches, suitable for analysis of PIN2 ubiquitylation and variations therein PMID: 25117288
10. Strigolactones (SLs) increase PIN2 polar localization, PIN2 endocytosis, endosomal trafficking, actin debundling and actin dynamics in a MAX2-dependent fashion. PMID: 24571327
11. we quantified directly and simultaneously the rate of PIN2 delivery of the newly synthesized protein into the plasma membrane as well as the disappearance of the protein from the plasma membrane due to degradation. PMID: 23637828
12. The exocyst is involved in PIN1 and PIN2 recycling, and thus in polar auxin transport regulation. PMID: 23163883
13. Consistent with SNX1's role in trafficking of the auxin efflux carrier PIN2, clasp-1 mutant plants have enhanced PIN2 degradation, and PIN2 movement to lytic vacuoles is rapidly induced by depolymerization of microtubules. PMID: 23477787
14. Dynamic adjustments in PIN2 ubiquitylation in gravity-stimulated roots, a response that coincides with establishment of a lateral PIN2 expression gradient. PMID: 22902683
15. PIN2 is involved in the PKS5-mediated signalling cascade under alkaline-stres and PIN2 is required for the maintenance of primary root growth in its adaptation to alkaline stress by modulating proton secretion in root tips. PMID: 23002434
16. Methyl jasmonate effects on PIN2 endocytosis and plasma membrane residence. PMID: 21466556
17. PIP5K2 is involved in regulating lateral root formation and root gravity response, and reveal a critical role of PIP5K2/PtdIns(4,5)P(2) in root development through regulation of PIN proteins, providing direct evidence of crosstalk between the phosphatidylinositol signaling pathway and auxin response, and new insights into the control of polar auxin transport PMID: 21894193
18. PIN2 is essential for robust root phototropism. Blue light-induced auxin flux in the root apex transition zone is dependent on PIN2, phot1, and NPH3 PMID: 22374399
19. PIN2 vacuolar sorting depends on modification specifically by lysine(63)-linked ubiquitin chains. PMID: 22556266
20. findings show that polar-competent PIN transporters for auxin are delivered to the center of polar domains by super-polar recycling; within the plasma membrane, PINs are recruited into non-mobile membrane clusters and their lateral diffusion is reduced PMID: 22027551
21. Data propose that MM31/EIR1 modulates lateral root formation by regulating the IAA polar transport system, and that auxin transport from the shoot to the root regulates lateral root formation. PMID: 21494100
22. Data suggest a role of gibberellic acid (GA) in Arabidopsis growth responses and for a GA-dependent modulation of PIN1, -2, and -3 turnover that may be causative for these differential growth responses. PMID: 21642547
23. Narciclasine modulates auxin transport gene expression and PIN2 localization. PMID: 21511360
24. These results reveal a plant-specific mechanism for cell polarity maintenance and provide a conceptual framework for modulating cell polarity and plant development. PMID: 21315597
25. data show that by directing polar PIN localization and PIN-mediated polar auxin transport, the three AGC3 kinases redundantly regulate cotyledon development, root meristem size and gravitropic response PMID: 20823065
26. PIN2 deployment in the cortex represents a mechanism for fine-tuning the flow of auxin as required for optimal responses within the zone of root elongation. PMID: 20562236
27. Cold stress inhibits the intracellular trafficking of auxin efflux carrier PIN2. PMID: 20040541
28. NOV is required for PIN2 polarity in the root cortex. PMID: 19880797
29. Alternative recruitment of PIN proteins by distinct pathways can account for cell type- and cargo-specific aspects of polar targeting, as well as for polarity changes in response to different signals. PMID: 19825603
30. Our data suggest that protein phosphatases, sensitive to cantharidin and okadaic acid, are likely involved in regulating AGR1/PIN2-mediated root basipetal auxin transport and gravitropism. [AGR1] [PIN2] PMID: 15807782
31. Redistribution of auxin during the gravitropic response may be involved in the regulation of PIN2 protein. PMID: 16489343
32. results demonstrate that PIN polarity is a primary factor in determining the direction of auxin flow in meristematic tissues PMID: 16601151
33. flavonoids promote asymmetric PIN shifts during gravity stimulation, thus redirecting basipetal auxin streams necessary for root bending. PMID: 18718912
34. The vacuolar targeting pathway is used by multiple cargos including PIN-FORMED (PIN) efflux carriers for the phytohormone auxin. PMID: 19004783
35. Plasma membrane accumulation of the auxin efflux transporter PIN2 requires the E3 ubiquitin ligase SCF(TIR1/AFB). PMID: 19218398
36. The loss of EIR1/AGR1/PIN2 function abolishes root curling of mlo4, mlo11, and wild-type seedlings. PMID: 19602625

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KEGG: ath:AT5G57090

STRING: 3702.AT5G57090.1

UniGene: At.9674