Recombinant Arabidopsis thaliana LRR receptor-like serine/threonine-protein kinase FLS2 (FLS2), partial

1. LLG1 constitutively associates with the PAMP receptor FLAGELLIN SENSING 2 (FLS2) and the elongation factor-Tu receptor, and forms a complex with BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 in a ligand-dependent manner, indicating that LLG1 functions as a key component of PAMP-recognition immune complexes PMID: 28507137
2. Combination of two identified mutations into a single allele further increased FLS2-mediated responses to the Erwinia amylovora flagellin peptide in Arabidopsis. PMID: 27270917
3. The study demonstrates that the G proteins are directly coupled to the FLS2 receptor complex and regulate immune signaling through both pre-activation and post-activation mechanisms. PMID: 27043937
4. MKKK7 negatively regulates FLS2 signaling and basal immunity. PMID: 26769563
5. We found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, we discovered that AVR3a associates with the Dynamin-Related Protein 2 (DRP2) PMID: 26348328
6. each investigated root tissue is able to perceive flg22 if FLS2 is present and that tissue identity is a major element of microbe-associated molecular patterns (MAMPs)perception in roots. PMID: 25627577
7. A tissue- and cell type-specific map of FLS2 expression has been created correlating with prominent entry sites and target tissues of plant bacterial pathogens. PMID: 25205577
8. Functionally redundant RXLR effectors from Phytophthora infestans act at different steps to suppress early flg22-triggered immunity. PMID: 24763622
9. FLS2 complexes regulate the expression of AtCLCd, further supporting a role for AtCLCd in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI). PMID: 24449384
10. Degradation of FLS2 plays a role in desensitizing Arabidopsis cells to bacterial flagellin or flg22 peptide. PMID: 24220680
11. Our findings identify that VPS37-1, and likewise VPS28-2, regulate late FLS2 endosomal sorting and reveals that ESCRT-I is critical for flg22-activated stomatal defenses involved in plant immunity PMID: 24385929
12. FLS2-BIK1 dissociation and FLS2-BAK1 association are not sufficient for FLS2-mediated defense activation, but the proposed FLS2 phosphorylation site Ser-938 and FLS2 kinase activity are needed for overall defense activation and for appropriate flg22-stimulated phosphorylation of BIK1 and homologs PMID: 23637603
13. The structural mechanism of the FLS2-flg22 interaction and subsequent receptor-mediated signalling. [Review] PMID: 23053766
14. these data reveals the molecular mechanisms underlying FLS2-BAK1 complex recognition of flg22 and provide insight into the immune receptor complex activation. PMID: 24114786
15. FLS2 localizes to bona fide endosomes via two distinct endocytic trafficking routes depending on its activation status. PMID: 23085733
16. FLS2 does not recognize CLV3 and that the shoot apical meristem is immune to bacteria independently of CLV3 perception. PMID: 22923673
17. The results indicate that ligand perception in FLS2 is a complex molecular process that involves LRRs from both the outermost and innermost LRRs of the FLS2 ectodomain. PMID: 22634763
18. FLS2 triggered activation of pathogenesis-related genes in Arabidopsis. PMID: 22080602
19. FLS2 is a PRR, which recognizes a part of bacterial flagellin. FLS2 forms a PTI signalling complex, some components of which are guarded by R proteins. PMID: 21726371
20. FLS2 functions beyond flagellin perception to detect other microbe-associated molecular patterns PMID: 21576467
21. Flagellin Sensitive2 (FLS2) accumulation was reduced in etr1 and ein2, indicating a requirement of ethylene signaling for FLS2 expression. PMID: 20592040
22. These results suggest a particularly important role of FLS2-mediated resistance to coronatine-deficient mutant Pst DC3000 bacteria. PMID: 20457804
23. FLS2 tolerated mild underglycosylation occurring in stt3a but was sensitive to severe underglycosylation induced by tunicamycin treatment PMID: 20007973
24. these results show that FLS2 constitutes the pattern-recognition receptor that determines the specificity of flagellin perception. PMID: 16377758
25. Species-specific differences in flagellin perception abilities to identify LeFLS2 as the flagellin receptor in Ararbidopsis. PMID: 17530419
26. Data suggest that the reduced mobility of FLS2 after binding flg22 and its existence in monomeric form are important mechanistic features of FLS2 early signaling. PMID: 17925310
27. we propose that both domains of Pseudomonas syringae pv tomato DC3000 AvrPtoB act together to support the virulence of PtoDC3000 in Arabidopsis through their ability to eliminate FLS2 from the cell periphery. PMID: 19062288

Show More

Hide All

KEGG: ath:AT5G46330

STRING: 3702.AT5G46330.1

UniGene: At.29960