Name: Recombinant DDB1- and CUL4-associated factor 11 homolog(wdr-23) ,partial
Brand: CUSABIO
SKU: 310862CXY

Product Details

Purity	>85% (SDS-PAGE)
Target Names	wdr-23
Uniprot No.	P90794
Alternative Names	wdr-23; D2030.9DDB1- and CUL4-associated factor 11 homolog; WD repeat-containing protein 23
Species	Caenorhabditis elegans
Protein Length	Partial
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form	Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet	Please contact us to get it.

Target Background

Function	Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). Inhibits the skn-1-mediated up-regulation of tatn-1.
Gene References into Functions	we identify and confirm the mutations in xrep-2, xrep-3, and xrep-4 The xrep-2 gene is alh-6, an ortholog of a human gene mutated in familial hyperprolinemia. The xrep-3 mutation is a gain-of-function allele of skn-1 The xrep-4 gene is F46F11.6, which encodes a F-box-containing protein. We demonstrate that xrep-4 alters the stability of WDR-23 (xrep-1), a key regulator of SKN-1 (xrep-3). PMID: 28428286 a missense mutation in the conserved XREP-4 F-box domain that reduces interaction with SKR-1 but not WDR-23 strongly attenuates SKN-1-dependent gene activation. These results are consistent with XREP-4 influencing the SKN-1 stress response by functioning as a bridge between WDR-23 and the ubiquitin ligase component SKR-1. PMID: 28341649 ur results identify WDR23 as an alternative regulator of NRF2 proteostasis and uncover a cellular pathway that regulates NRF2 activity and capacity for cytoprotection independently of KEAP1. PMID: 28453520 We also show that SKR-1/2 functions upstream of the WD40 repeat protein WDR-23, which binds to and inhibits SKN-1. Together, these results identify a novel p38 MAPK independent signaling mechanism that activates SKN-1 via SKR-1/2 and involves WDR-23. PMID: 27776126 diverse wdr-23 phenotypes are dependent on SKN-1; beneficial and detrimental phenotypes of wdr-23 and skn-1 can be partially decoupled; SKN-1 activation delays degenerative tissue changes during aging PMID: 26056713 Data show that SKN-1 protein levels, nuclear accumulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL-4/DDB-1 ubiquitin ligase to presumably target the transcription factor for proteasomal degradation. PMID: 19273594 Show More Hide All
Protein Families	WD repeat LEC14B family
Database Links	KEGG: cel:CELE_D2030.9 STRING: 6239.D2030.9a.2 UniGene: Cel.17236

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Code	CSB-YP310862CXY
Size	Pls inquire
Source	Yeast
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Code	CSB-EP310862CXY
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Source	E.coli
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Code	CSB-EP310862CXY-B
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP310862CXY
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP310862CXY
Size	Pls inquire
Source	Mammalian cell
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Recombinant DDB1- and CUL4-associated factor 11 homolog(wdr-23) ,partial

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