Recombinant Drosophila melanogaster Apoptosis 1 inhibitor (th)

1. Both germline and somatic stem cells in the adult Drosophila testis are more resistant to apoptosis-inducing stimuli than their differentiating daughters. Niche signaling causes enhanced expression of DIAP1 in both germline stem cells and somatic cyst stem cells, and the resistance to apoptosis is mediated, at least in part, by this enhanced expression. PMID: 25941003
2. DIAP1 contains distinct instability motifs that regulate inhibitor-of-apoptosis turnover and apoptotic consequences. PMID: 25653450
3. This study showed that Diap2 could be regulating ion channels, as loss of Diap2 consequently reduces the expression of ion channels and affects the balance of ion concentrations which results in reduced uric acid deposition. PMID: 24374974
4. DIAP1 is an important survival factor that inhibits premature death of CCAP-expressing neurons. PMID: 23784845
5. dBruce inhibits apoptosis by promoting IAP-antagonist ubiquitination on unconventional acceptor sites. PMID: 21886178
6. Drosophila CtBP (dCtBP) was identified as a binding partner of Diap1; whether the interaction between Diap1 and dCtBP also occurs in human cells was tested. PMID: 22138398
7. DIAP1-mediated ubiquitylation does not trigger proteasomal degradation of full-length DRONC, but serves a non-proteolytic function PMID: 21909282
8. The cleaved DIAP1 binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation. PMID: 21811237
9. host pathway initiated by virus DNA replication and acting through instability motifs within IAP triggers IAP depletion and causes apoptosis; suggests host modulation of IAP levels is mechanism by which insects mount an apoptotic antiviral response PMID: 21653668
10. the anti-apoptotic factor drosophila inhibitor of apoptosis 1 protein is downregulated in these cells in a head involution defect protein-dependent manner PMID: 21113144
11. VCP binds to DIAP1 in a ubiquitin- and BIR domain-dependent manner and facilitates its degradation, therefore establishing a new link between ubiquitin, dendrite pruning and the apoptosis machinery. PMID: 21343367
12. Results suggest that the hsromega transcripts regulate cellular levels of DIAP1 via the hnRNP Hrb57A, which physically interacts with DIAP1. PMID: 19737742
13. the existence of a novel mechanism for cell death signaling in Drosophila that is mediated by DRONC and Dark. PMID: 12011068
14. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms PMID: 12021767
15. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. PMID: 12021769
16. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from this protein PMID: 12356728
17. DIAP1 is required to prevent excess accumulation of the first form of processed DRONC, presumably through its ability to act as a ubiquitin-protein ligase PMID: 12397080
18. DIAP1 is degraded by the 'N-end rule' pathway and this process is indispensable for regulating apoptosis. Caspase-mediated cleavage of DIAP1 at position 20 converts DIAP1 into an unstable, Asn-bearing, DIAP1 N-degron of the N-end rule degradation pathway. PMID: 12692559
19. Overexpression of Diap1 suppressed cell death induced by dcp-1 but had no effect on cell death during late oogenesis. PMID: 12885559
20. data strongly suggest that inhibitors of apoptosis 1 destabilization by Reaper in intact cells requires localization to mitochondria and that induction of this instability is important for the potent induction of apoptosis in Drosophila cells PMID: 12917412
21. Overexpression of IAP1 suppressed cell migration and did not cause apoptosis. PMID: 15242648
22. model for DIAP1 function in living and dying cells PMID: 15371434
23. DIAP1-sequestered effector caspases remain catalytically active, suggesting that DIAP1 does not function as a bona fide enzyme inhibitor PMID: 15580265
24. IKK epsilon function involves the negative regulation of the nonapoptotic activity of DIAP1. PMID: 16887350
25. dOmi alleviates Drosophila inhibitor of apoptosis 1 inhibition of all caspases by proteolytically degrading Drosophila inhibitor of apoptosis 1 and induces apoptosis both in cultured cells and in the developing fly eye PMID: 17557079
26. findings suggest that DIAP1 is a critical sensor of RNA virus infection, which upon virus-signaled depletion relieves caspase inhibition, which subsequently executes apoptotic death. PMID: 17989181
27. Data show that DIAP1 auto-ubiquitination and degradation was contributed by both Reaper binding and mitochondrial localization. PMID: 17998202
28. our results suggest that the level of eIF4E protein is regulated by Diap1, and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein. PMID: 18182863
29. The binding of DIAP1 to dOmi resulted in DIAP1-mediated polyubiquitination of dOmi, suggesting that DIAP1 could target dOmi for proteasomal degradation. PMID: 18259196
30. Because DIAP1 prevents apoptosis after a variety of stresses, STAT92E may have a role in regulating stress responses in general PMID: 18779571
31. suggest that HOW(L) enhances the sensitivity of MG cells to apoptotic signals by reducing the levels of diap1 in these cells in, demonstrating a novel mode of regulation of PCD at the mRNA level PMID: 18984040
32. found that the quantity of DIAP1 changed dramatically depending on the cell type and maturity. PMID: 19822670

Show More

Hide All

KEGG: dme:Dmel_CG12284

STRING: 7227.FBpp0305795

UniGene: Dm.6466