Recombinant Drosophila melanogaster Caspase Nc (Nc)

1. Dronc plays a dual role that can either initiate DNA damage response or apoptosis. PMID: 28751499
2. Dronc protein fails to accumulate in epithelial cells with impaired proteasome function suggesting that it is not degraded by the proteasome. PMID: 27104928
3. e provide evidence that not all of the non-apoptotic functions of Dronc require its catalytic activity. In conclusion, we demonstrate a mechanism whereby Dronc's apoptotic and non-apoptotic activities can be kept silenced in a non-degradative manner through a single ubiquitylation event in living cells. PMID: 28207763
4. the principal caspase required for the cleavage of Inhibitor of Apoptosis 2 Protein PMID: 25968339
5. Findings suggest that the intrinsic properties of initiator caspase Dronc proteinsare responsible, at least in part, for the differing sensitivity of Ld652Y and BM-N to apoptosis induction upon nucleopolyhedroviruses (NPVs) infection. PMID: 23743202
6. that DRONC protein accumulates in "undead" cells due to increased transcription of dronc in these cells PMID: 21909282
7. Data suggest that the cleaved-Caspase-3 antibody recognizes multiple proteins including DCP-1 and likely DRICE, but also at least one additional unknown protein, all of which require DRONC for epitope exposure. PMID: 19960024
8. mutations in Dronc, the Drosophila ortholog of initiator caspase-9, attenuated dendritic pruning more efficiently than inhibition of the effector caspases, transgenic expression of WldS, or both, indicating additional roles of Dronc in this process PMID: 20445064
9. Cell death stimulated by POSH is dependent on the caspase-9 homolog, Drosophila Nc. PMID: 20014406
10. a novel cell death pathway triggered by DIAP1 depletion depends on Dark and Dronc PMID: 12011068
11. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. PMID: 12021771
12. DRONC caspase is regulated by ecdysone during apoptosis in Drosophila. The BR-C transcription factor regulates ecdysone during metamorphosis. PMID: 12045184
13. Jafrac2 displaces Dronc from DIAP1 by competing with Dronc for the binding of DIAP1, consistent with the idea that Jafrac2 triggers cell death by liberating Dronc from DIAP1-mediated inhibition PMID: 12356728
14. the initial step in DRONC processing occurs continuously via a DARK-dependent mechanism in Drosophila cells and DIAP1 is required to prevent excess accumulation of this first form of processed DRONC PMID: 12397080
15. the dronc promoter is regulated in a highly complex manner PMID: 12970673
16. Direct binding of EcR-Usp is crucial for controlling the timing of dronc expression in specific tissues. PMID: 15173191
17. analysis of Dronc activation and processing in Drosophila cells PMID: 15383617
18. dronc has a role in regulating programmed and unprogrammed cell death in Drosophila PMID: 15572131
19. DRONC is involved in specific developmental cell death pathways PMID: 15572132
20. DIAP1 is cleaved by the apical caspase DRONC in both normal and apoptotic Drosophila cells PMID: 15774476
21. Our study places DRONC at a central point of convergence for multiple cell death pathways and for the ecdysone pathway regulating metamorphosis PMID: 15922568
22. [extra views]Insights gained from the dronc mutants will help in advancing our understanding of caspase function in various developmental pathways. PMID: 15970694
23. These results show that the apoptotic pathway bifurcates at DRONC and that DRONC coordinates the execution of cell death and compensatory proliferation. PMID: 16980627
24. Results describe the activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. PMID: 18309328

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KEGG: dme:Dmel_CG8091

STRING: 7227.FBpp0076076

UniGene: Dm.3230