Recombinant Drosophila melanogaster Heterochromatin protein 1 (Su (var)205)

1. we show that Heterochromatin Protein 1a is required for the production of piRNAs coming from telomeric transposable elements. Furthermore, as in adult ovaries, incomplete, bimodal, and stochastic repression resembling variegation can occur at all developmental stages PMID: 27932388
2. Knockdown of both HP1a and Mcm10 genes inhibited the progression of S phase in eye imaginal discs. Proximity Ligation Assay (PLA) demonstrated that HP1a is in close proximity to DNA replication proteins including Mcm10, RFC140 and DNA polymerase epsilon 255 kDa subunit in S-phase. PMID: 28180289
3. Recruitment of either HP1GAL4DBD or SUURGAL4DBD resulted in delayed completion of replication PMID: 25398563
4. Results show that HP1 interacts with Med26. PMID: 24820420
5. found that HP1a selectively associated with a broad set of RNAs transcribed from repetitive regions PMID: 24990964
6. studies indicate that the binding surface of the HP1a CSD plus its short CTE provide the needed discrimination among HP1a's partners, and that the CTE is important for differentiating the interactions of the Drosophila HP1 paralogs PMID: 23793104
7. HP1a has opposite functions in different genomic regions, repressing expression on chromosome 4 and stimulating expression in pericentromeric regions. PMID: 23476027
8. Our results support a hypothesis in which HP1a nucleates with high affinity independently of H3K9me in promoters of active genes and then spreads via H3K9 methylation and transient looping contacts with those H3K9me target sites PMID: 23166515
9. The HP1a-enriched, POF-associated chromatin structure over the gene bodies may represent one type of adaptation for genes embedded in repetitive DNA. PMID: 23028361
10. binding to HP1a is required for dKDM4A-mediated H3K36me3 demethylation at a subset of heterochromatic genes. Collectively, these results show that HP1a functions to target the H3K36 demethylase dKDM4A to heterochromatic genes in Drosophila PMID: 22761891
11. Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them. PMID: 22682252
12. eyg has a dose-dependent effect on heterochromatin gene silencing and identifies a genetic interaction with HP1a in this process. PMID: 22547675
13. studies underscore the importance of chromo shadow domain dimerization and cooperation with the C-terminal extension in forming distinct complexes of HP1a PMID: 21472955
14. Enrichment of the Drosophila Smc5/6 complex in heterochromatin requires HP1a PMID: 21353298
15. Data show that animals with reduced heterochromatin, such as Stat92E transheterozygotes, Su(var)205 heterozygotes, or Su(var)3-9 transheterozygotes, were less viable than wild-type controls. PMID: 20847228
16. TP5 represses the excision of other P elements in the germ line through a combination of maternal and zygotic effects. The maternal component of this repression is impaired by heterozygous mutations in the Suppressor of variegation 205 genes. PMID: 20943007
17. HP1c functions to recruit the FACT complex to RNA polymerase II PMID: 20889714
18. observation of opposing functions of HP1 suggests a model where HP1-mediated repeat inactivation or replication complex loading on the chromosome arms is required for proper activation of origins of replication PMID: 20435908
19. Mutation of AGO2 or piwi increases silencing at piRNA clusters corresponding to an increase of HP1 association. PMID: 20300658
20. HP1 takes part in multiple mechanisms of silencing and spreading PMID: 19487560
21. structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing, are presented PMID: 11859155
22. Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogaster. PMID: 11940677
23. an HP1-interacting protein, heterochromatin protein 2 (HP2), which codistributes with HP1 in the pericentric heterochromatin PMID: 12376620
24. HP1 could organize peripheral heterochromatin and contribute in the compartmentalization of the cell nucleus [review] PMID: 12490149
25. HP1 plays an important role in regulating the expression of many different euchromatic regions PMID: 12723693
26. HP1 is positively involved in euchromatin Hsp70 gene activity PMID: 12756231
27. mutations in piwi, aubergine, or spindle-E which encode RNAi components result in delocalization of HP1 PMID: 14752161
28. Data suggest that HP1-mediated silencing can operate in a SU(VAR)3-9-independent and -dependent manner. PMID: 15215206
29. Mutations can suppress w+ variegation if w+ transgene integrates into Chromosome 4. PMID: 15579693
30. Data demonstrate multiple mechanisms for HP1 localization within euchromatin and show that some genes associated with HP1 are not affected by alterations in its gene dosage. PMID: 15704177
31. Heterochromatin protein 1 appears to be essential for the maintenance of cell-cycle progression and the transcription of cell-cycle regulatory genes PMID: 15905474
32. Although structurally very different, HP1 and Su(var)3-7 participate closely in chromocenter and male X polytene chromosome integrity. PMID: 16234327
33. HP1 modulates chromosomal integrity, histone modifications and transcription in a sex-specific manner. PMID: 16258543
34. Results suggest that displacement of the heterochromatin proteins D1, HP1 and topoisomerase II from satellite III result in stochastic chromatin opening and desilencing of the nearby white gene in white-mottled flies. PMID: 16675949
35. HP1 has multiple target sites that contribute to its recognition of chromatin, only one of them being methylated at H3K9. PMID: 17101786
36. Pericentric heterochromatin is heterogeneous in its requirement for SU(VAR)3-9 with respect to the establishment of the condensed state, time of replication, and DNA polytenization. PMID: 17151257
37. HP1 acts as a docking platform for several mediator proteins that contribute to heterochromatin function. PMID: 17255947
38. There is a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome. PMID: 17318176
39. These results demonstrate that HP1-chromatin is transcriptionally active and has extensive links with several other chromatin components. PMID: 17335352
40. PIWI, like HP1a, is itself a chromatin-associated protein whose distribution in polytene chromosomes overlaps with HP1a and appears to be RNA dependent. PMID: 17875665
41. These results suggest a balancing mechanism for the regulation of the fourth chromosome where POF and HP1 competitively bind at increasing levels with increased transcriptional activity. PMID: 18020713
42. Hip cooperates with HP1 in chromatin remodeling and gene silencing PMID: 18162556
43. Data show that Drosophila STAT (STAT92E) is involved in controlling heterochromatin protein 1 (HP1) distribution and heterochromatin stability. PMID: 18344984
44. it is proposed that interaction of SUUR with HP1 is crucial for the association of SUUR with chromatin PMID: 18445687
45. protein localises primarily to the heterochromatin at the chromocentre on salivary gland polytene chromosomes. PMID: 18461125
46. HP1 is distributed within distinct chromatin domains at Drosophila telomeres PMID: 18723888
47. These results suggest a function of HP1a in transcription facilitating H3K36 demethylation at transcribed and/or heterochromatin regions. PMID: 19061644
48. HP1 interacts with Umbrea with functional role in mediating normal telomere behaviour in Drosophila PMID: 19190990
49. HP1a positively regulates euchromatic gene expression through interaction with hnRNPs. PMID: 19798443

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KEGG: dme:Dmel_CG8409

STRING: 7227.FBpp0079251

UniGene: Dm.3713