Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2(EBNA2),partial,Yeast

In Stock
Code CSB-YP718162EEZ(A4)
Product Type Recombinant Protein
Size US$335Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q69022
Lead Time 3-7 business days
Abbreviation EBNA2
Storage Buffer Tris-based buffer,50% glycerol
Species Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Purity >85% (SDS-PAGE)
Sequence MPTYYLALHG GQSYNLIVDT DMSGNPSLSV IPTNPYQEQL SNNPLIQLQI VVGENTGAPA PPQPPPPPPP PPPPERRDAW TQEPLPLDMN PLGSDASQGP LASSIRMLCM AQYLLRNARG QQGLLRPLGP QTRSQVTLER QPVHNPRQEA PIILLQSPAP PRFTPVPMVA LGHTLQPTPP PRPTLPQPRI PLIIPPRHTN QPATTPPTAP QRLTLGHQLS LPPHPPPHQS TPHCSSDSTG LPPPPTSYSI PSMTLSPEPL PPPAAPAHPL PGVIYDQQAL PPTPGPPWWP PVRDPTPTTQ TPPTNTKQGP DQGQGRGRWR GRGRSKGRGR MHKLPEPRRP GPDTSSPSMP QLSPVVSLHQ GQGPENSPTP GPSTAGPVCR VTPSATPDIS PIHEPESSDS EEPPFLFPSD WYPPTLEPAE LDESWEGIFE TTESHSSDEE NVGGPSKRPR TSTQ
Source Yeast
Gene Names EBNA2
Protein Names Recommended name: Epstein-Barr nuclear antigen 2 Short name= EBNA-2 Short name= EBV nuclear antigen 2
Expression Region 247-454aa
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
Protein Description Partial
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells (By similarity).
Subcellular Location Host nucleus matrix
Protein Families Herpesviridae EBNA2 family
Database Links

KEGG: vg:5176198

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