Recombinant Epstein-Barr virus Epstein-Barr nuclear antigen 2(EBNA2),partial,Yeast

In Stock
Code CSB-YP718162EEZ(A4)
Size US$1916 How to order?
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Product Details

Purity >85% (SDS-PAGE)
Target Names EBNA2
Uniprot No. Q69022
Alternative Names EBNA2; BYRF1Epstein-Barr nuclear antigen 2; EBNA-2; EBV nuclear antigen 2
Species Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
Source Yeast
Expression Region 247-454aa
Target Protein Sequence MPTYYLALHG GQSYNLIVDT DMSGNPSLSV IPTNPYQEQL SNNPLIQLQI VVGENTGAPA PPQPPPPPPP PPPPERRDAW TQEPLPLDMN PLGSDASQGP LASSIRMLCM AQYLLRNARG QQGLLRPLGP QTRSQVTLER QPVHNPRQEA PIILLQSPAP PRFTPVPMVA LGHTLQPTPP PRPTLPQPRI PLIIPPRHTN QPATTPPTAP QRLTLGHQLS LPPHPPPHQS TPHCSSDSTG LPPPPTSYSI PSMTLSPEPL PPPAAPAHPL PGVIYDQQAL PPTPGPPWWP PVRDPTPTTQ TPPTNTKQGP DQGQGRGRWR GRGRSKGRGR MHKLPEPRRP GPDTSSPSMP QLSPVVSLHQ GQGPENSPTP GPSTAGPVCR VTPSATPDIS PIHEPESSDS EEPPFLFPSD WYPPTLEPAE LDESWEGIFE TTESHSSDEE NVGGPSKRPR TSTQ
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Protein Length Partial
Tag Info N-terminal His-tagged
Tag-Free
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time 3-7 business days
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

Function
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells.
Subcellular Location Host nucleus matrix.
Protein Families Herpesviridae EBNA2 family
Database Links

KEGG: vg:5176198

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