Recombinant Escherichia coli Uncharacterized HTH-type transcriptional regulator ydjF (ydjF)

The protein YdjF is a significant component in bacterial stress response systems. It exhibits homology to the PspA protein of E. coli [1]. Additionally, it has been shown to be highly induced by alkali stress and phage infection in a W-dependent manner [2]. Furthermore, a conserved partner of PspA in these systems is a membrane-associated protein with a "TPM phosphatase domain" known as YdjH [3]. These findings suggest that YdjF plays a crucial role in the bacterial stress response, particularly in the context of alkali stress and phage infection, and is closely associated with the PspA protein and YdjH. Therefore, YdjF is an essential protein involved in the stress response and adaptation of bacteria to various environmental challenges.

References:
[1] T. Wiegert, G. Homuth, S. Versteeg, & W. Schumann, "Alkaline shock induces the bacillus subtilisσw regulon", Molecular Microbiology, vol. 41, no. 1, p. 59-71, 2001. https://doi.org/10.1046/j.1365-2958.2001.02489.x
[2] A. Schmid, H. Howell, J. Battista, S. Peterson, & M. Lidstrom, "Global transcriptional and proteomic analysis of the sig1 heat shock regulon ofdeinococcus radiodurans", Journal of Bacteriology, vol. 187, no. 10, p. 3339-3351, 2005. https://doi.org/10.1128/jb.187.10.3339-3351.2005
[3] J. Ravi, V. Anantharaman, S. Chen, P. Datta, L. Aravind, & M. Gennaro, "The phage-shock-protein (psp) envelope stress response: discovery of novel partners and evolutionary history",, 2020. https://doi.org/10.1101/2020.09.24.301986