Recombinant Human ATPase inhibitor, mitochondrial (ATPIF1)

1. Results presently demonstrate, both in vitro and in vivo, that polycyclic aromatic hydrocarbons, especially B[a]P, strongly increase IF1 expression. Such an increase, which might rely on beta2-adrenergic receptor activation, notably participates to the B[a]P-induced glycolytic shift and cell survival in liver cells. PMID: 28298645
2. results suggest that IF1 overexpression promotes cancer cells survival under temporary anoxic conditions by preserving cellular ATP despite mitochondria dysfunction. PMID: 29097244
3. IF1 suppresses programmed cell death. PMID: 28228254
4. reverse phase protein microarrays identified the glycolysis promoting PKM2 and IF1 proteins as specific biomarkers of dermatomyositis. PMID: 28183315
5. CF6-induced increase in apoptotic cells was blocked by immature or mature IF1, being accompanied by protein kinase B (PKB) phosphorylation. IF1 antagonizes the pro-apoptotic action of CF6 by relief of intracellular acidification and resultant phosphorylation of PKB. PMID: 26659871
6. The potential role of mitochondrial ATPIF1 in coronary heart disease was reviewed. PMID: 28173810
7. this study shows that abnormal expression of ATPase inhibitor, mitochondrial isoform 1 precursor(IF1) may relate to the hyperfunction of immune responses and excessive apoptosis of severe aplastic anemia CD34(+) cells PMID: 27086042
8. These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience PMID: 26484591
9. Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1). PMID: 26595676
10. Upon IF1 interaction with the ATP synthase both the synthetic and hydrolytic activities of the engine of oxidative phosphorylation are inhibited. (Review) PMID: 26876430
11. PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase. PMID: 26387949
12. IF1 was overexpressed in bladder cancer; concluded that IF1 may be a novel therapeutic target for bladder cancer PMID: 26381881
13. These results indicate that IF1 may serve as a prognostic marker and promotes tumor growth and metastasis in gastric cancer. PMID: 25776485
14. interaction of IF1 with the complex either directly, by increasing the catalytic activity of the enzyme, or indirectly, by improving the structure of mitochondrial cristae, can increase the oxidative phosphorylation rate in osteosarcoma cells PMID: 25605724
15. Inhibition of ATPIF1 ameliorates complex III blockade in primary hepatocytes, a cell type afflicted in severe mitochondrial disease. PMID: 24685140
16. promotes hepatocellular carcinoma angiogenesis and metastasis by up-regulation of Snai1 and VEGF transcription PMID: 25042864
17. ATPase inhibitory factor 1 (ATPIF1/IF1) was identified as essential for PARK2 recruitment and mitophagy in cultured cells. PMID: 24005319
18. The expression of human ATPase inhibitory factor 1 (hIF1) inhibits the activity of oxidative phosphorylation and mediates the shift of neurons to an enhanced aerobic glycolysis. PMID: 24521670
19. IF1 as a new determinant of HDL-C that is inversely associated with CHD PMID: 23794714
20. Activation of IF1 degradation acts as the switch that regulates energy metabolism during osteogenic differentiation. PMID: 23722655
21. IF1 overexpression is associated with preservation of mitochondrial morphology and ultrastructure, consistent with a central role for IF1 as a determinant of inner membrane architecture and with the role of mitochondrial ultrastructure in the regulation of Cyt c release; data suggest IF1 is an antiapoptotic and potentially tumorigenic factor PMID: 23348567
22. the identification of mitochondrial Atpif1 as a regulator of haem synthesis advances our understanding of the mechanisms regulating mitochondrial haem homeostasis and red blood cell development PMID: 23135403
23. The mitochondrial ATPase inhibitory factor 1 triggers a reactive oxygen species -mediated retrograde prosurvival and proliferative response. PMID: 22342343
24. Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis. PMID: 20538613
25. the ATPIF1 gene is not considered to contribute to a Chinese family affected with benign familial infantile seizures. PMID: 20374090
26. The function of ATPase inhibitor protein in the plasma membrane of endothelial cells is probably not limited to regulation of F1F0-ATP synthase catalysis. PMID: 15809073
27. IF(1)-Ca(2+)-CaM complex, forming on plasma membrane, functions in the cellular regulation of HDL endocytosis by hepatocytes. PMID: 17851741

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HGNC: 871

OMIM: 614981

KEGG: hsa:93974

STRING: 9606.ENSP00000335203

UniGene: Hs.744914