Recombinant Human Alcohol dehydrogenase 1C(ADH1C)

Code CSB-EP001355HU
Size US$1726
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names ADH1C
Uniprot No. P00326
Research Area Signal Transduction
Alternative Names ADH gamma subunit; ADH1C; ADH1G_HUMAN; Adh3; Alcohol dehydrogenase 1C (class I) gamma polypeptide; Alcohol dehydrogenase 1C; Alcohol dehydrogenase 1C gamma polypeptide; Alcohol dehydrogenase 3 (class I) gamma polypeptide; Alcohol dehydrogenase 3; Alcohol dehydrogenase subunit gamma; Aldehyde reductase; Class I alcohol dehydrogenase; OTTHUMP00000220209
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-375aa
Target Protein Sequence STAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 66.7kDa
Protein Length Full Length
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Gene References into Functions
  1. The influence of ADH3 genetic polymorphisms on the status of liver function showed significant difference according to GGT measurement, but the same cannot be said on the other two values measuring SGOT and SGPT. PMID: 28239076
  2. Expression of xylanase under the regulation of ADH3, AOX1 and GAP was compared.The highest enzyme production was obtained with AOX1 culture at shake-flask level.The PADH3 cultures were more productive than AOX1 and GAP at fermentor scale PMID: 26835836
  3. The ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk. PMID: 26634490
  4. the combination of genotypes ADH2 * 2, CYP2E1 * 1 combined with genotype homozygous ALDH2 * 1 found in this study could be leading to the population to a potential risk to alcoholism. The role of ADH3 was not indicated. PMID: 26848198
  5. Thus these findings suggest that the three variants of ADH1C, MnSOD and GSTM1 can be used to identify individuals who are at high risk to develop ALD and may be helpful in proper management of Indian alcoholics PMID: 26937962
  6. Results show that mutation of this protein confers associated protection against alcohol dependence. However these associations were not completely independent PMID: 24735490
  7. Among the Inuit in Greenland, ADH1C SNPs play a role in shaping their alcohol drinking patterns. PMID: 25311581
  8. findings suggest that ADH1C*2 is associated with alcohol dependence in the Turkish population displaying a dominant inheritance model. ADH1C*2 allele may contribute to the variance in heritability of alcohol dependence. PMID: 25372623
  9. Young male East Indians with at least one ADH1C*2 allele feel less effects of alcohol, including nausea. PMID: 25208201
  10. a positive association between inactive ADH1C G allele and alcohol consumption regarding gastric cancer risk was found, opposite to that found in previous studies PMID: 25524923
  11. Decreased expression of ADH1C gene is associated with disease progression. PMID: 24599561
  12. Alcohol dehydrogenase (ADH)1B and ADH1C are jointly associated with alcohol use disorders, but not consumption. PMID: 23895337
  13. additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence PMID: 23516558
  14. ADH1C polymorphism is not associated with childhood acute leukemia and maternal caffeinated beverage consumption during pregnancy. PMID: 23404349
  15. study failed to find any link between the ADH1C genotype and the cardioprotective effects of alcohol PMID: 23321361
  16. did not observe association of ADH1C polymorphism with esophageal cancer PMID: 22930414
  17. The frequency of ALDH2*2 and ADH3*1 alleles in risk drinkers was lower than that in safe drinkers in a male Tibetan population. PMID: 22279680
  18. No associations between alcohol dependence and polymorphisms in ADH1C were found in Mexican and Native Americans PMID: 22931071
  19. Findings suggest that a significantly higher presence of ADH1C*2 allele is associated with alcohol dependence in a Turkish population. PMID: 22414625
  20. This meta-analysis suggests that ADH1C polymorphism may not be associated with breast cancer development in Caucasians. PMID: 22353233
  21. ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians. PMID: 22675424
  22. findings support that ADH1C Ile may lower the risk of alcohol dependence and alcohol abuse as well as alcohol-related cirrhosis in pooled populations, with the strongest and most consistent effects in Asians PMID: 22476623
  23. in a study of alcohol metabolic genotypes in drunk drivers, the rs698 ADH1C and rs671 ALDH2 polymorphisms were not associated with MCV PMID: 21917409
  24. No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected. PMID: 22325912
  25. This study shows differences in the distribution of the frequency of allele ADH1C*1 between the Basque Country and Moroccan populations, and a new allele not described to date. PMID: 21303386
  26. This study suggested that the ADH1C Sspl polymorphism could play a significant role in the etiology of oral cancer. PMID: 21705789
  27. The presence of ADH3 in normal lung development (A549 cell line), & the capacity to convert retinol to retinoic acid, indicates that fetal human lung has the ability to regulate the supply of vitamin A from the pseudoglandular stage. PMID: 21482329
  28. the ADH1C*2/*2 genotype was associated with a 42% increase in risk of colorectal cancer when compared with the ADH1C*1/*1 genotype. PMID: 21163612
  29. Polymorphisms in ADH1C is associated with pancreatic cancer. PMID: 19068087
  30. The increased risk of oral clefts was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism. PMID: 20810466
  31. These findings suggest that a lower presence of ADH1C*1 allele is associated with squamous cell carcinoma of the head and neck PMID: 20448861
  32. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day. PMID: 20350778
  33. Results suggest that the ADH1C allele modifies the carcinogenic dose response for alcohol in the upper aerodigestive tract, giving rise to a gene-environment interaction. PMID: 20437850
  34. ADH1C polymorphisms were not significantly associated with pancreatic cancer risk. PMID: 19812523
  35. Besides the identification of new genetic factors related to alcohol biodisposition relevant to whites, this study provides unambiguous identification of diplotypes related to variability in alcohol biodisposition. PMID: 20101753
  36. ADH1C gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
  37. Report associations between genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors. PMID: 19447389
  38. A new coding variant has been identified at codon 351 of ADH1C, an allele found in most Native American populations studied, with allele frequencies of the new ADH1C*351Thr allele as high as 26%. PMID: 12500098
  39. Results suggest that alcohol dehydrogenase 3 catalysed S-nitrosoglutathione reduction is of physiological relevance in the metabolism of NO in humans. PMID: 12631283
  40. There is no significant interaction between alcohol consumption and ADH3 genotype. PMID: 12658118
  41. adh3 gene is implicated in alcoholism incidence among African Americans PMID: 12713190
  42. gastric ADH3 may highly effectively contribute to the first-pass metabolism at 0.5-3 M ethanol, an attainable range in the gastric lumen during alcohol consumption PMID: 12782305
  43. mutations in genes encoding ADH1C (G78Stop) as genetic risk factors for Parkinson disease . PMID: 15642852
  44. ADH1C polymorphisms in the cis-acting elements affect transcription. PMID: 15643610
  45. a slower alcohol clearance rate is associated with the ADH3 y2 allele [letter] PMID: 15842377
  46. mean corpuscular volume values were not associated with genotype polymorphisms of ADH1C PMID: 15897724
  47. No association has been revealed for the alcohol metabolism-related ADH3 genotype and Korean patients with alcoholism compared to Korean control subjects without alcoholism. PMID: 15902904
  48. Conversely, in both genders, no differences were found between ADH3 genotypes regarding all cardiovascular risk factors studied and carotid intima-media thickness. PMID: 15941567
  49. ADH1C genotype modifies the association between alcohol consumption and HDL levels among men and postmenopausal women not using postmenopausal hormones who drink moderately PMID: 16051248
  50. Alcohol dehydrogenase 3 null genotypes did not modify the risk of HCC due to alcohol intake. PMID: 16132793
  51. No effects of the ADH1C*349Ile alleles on in vivo ethanol metabolism were observed. This implies that there is a major determinant of variation for in vivo alcohol metabolism in the ADH region that is not accounted for by this polymorphism. PMID: 16184481
  52. HNF1 binding, at approximately 51 kb upstream, plays a master role in controlling human class I alcohol dehydrogenase gene expression. PMID: 16675441
  53. Genetic polymorphisms of ADH1C is associated with oral and pharyngeal squamous cell carcinoma PMID: 17071628
  54. These results suggest that ADH1C polymorphisms are associated with alcohol dependence and alcohol associated elevations of liver enzymes in a population with a low frequency of ADH1B2 alleles. PMID: 17134660
  55. Polymorphisms in ADH1C is associated with breast cancer PMID: 17268812
  56. Low levels of alcohol are associated with a modest increase in breast cancer risk that is not altered by known functional allelic variants of the ADH1C gene. PMID: 17295732
  57. Our findings do not support the hypothesis that ADH1C variants are associated with coronary heart disease risk in people who drink moderately. PMID: 17379229
  58. The researchers found evidence for a functional allele polymorphic with a strong specific linkage disequilibrium in an Indian population, and this is an important factor in the metabolism of ethanol to acetaldehyde. PMID: 17421009
  59. The ADH1C*1 allele frequency and rate of homozygosity was significantly associated with an increased risk for alcohol-related cancer. PMID: 17543846
  60. examined genetic polymorphisms in the alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 genes in 505 patients with histologically confirmed lung cancer and 256 noncancer controls to determine association with alcohol drinking PMID: 17559142
  61. ADH1C*2 allele, related to slower oxidation rate, attenuates the lower diabetes risk among moderate to heavy drinkers. PMID: 17563066
  62. Data suggest that ADH3 genotype may be associated with risk of esophageal and stomach cardia adenocarcionoma. PMID: 17665311
  63. individuals with ADH1C slow vs fast alcohol degradation had a higher risk of heavy and excessive drinking. PMID: 17923853
  64. Alcohol dehydrogenase modifies the effect of alcohol consumption on coronary risk. The results support the protective effect of alcohol consumption on CHD risk and suggest a causal association of alcohol intake and lower CHD risk. PMID: 18043297
  65. It was observed that ADH variants, ADH2*1 and ADH3*2, were associated with increased risk for oesophageal cancer, possibly due to the tolerance of the carriers of these alleles to alcohol consumption PMID: 18254707
  66. study suggests the association of ADH1C*2/*2/MTHFR 677TT genotype combination as a risk factor for oral squamous cell carcinoma in alcoholics PMID: 18266839
  67. Polymorphisms in ADH1C may not be associated with risk of colorectal adenoma, but may interact with nutrients in the one-carbon pathway to affect adenoma risk. PMID: 18268116
  68. Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors PMID: 19038239
  69. ADH1C homozygosity is a genetic risk marker for colorectal tumors in individuals consuming more than 30 g alcohol per day. PMID: 19120062
  70. Results suggest a slightly increased risk of larynx cancer for indeividuals who have inherited the ADH1C*1 allele, however results were not at statistic significance level. PMID: 19189524
  71. ADH1C genotypes were not associated with and did not modify the effect of alcohol on biochemical tests or risk of liver disease. PMID: 19550411
  72. Polymorphisms in the untranslated regions of ADH class I genes were demonstrated to clearly affect individual differences in alcohol metabolism. PMID: 19618839

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Subcellular Location Cytoplasm
Protein Families Zinc-containing alcohol dehydrogenase family
Database Links

HGNC: 251

OMIM: 103730

KEGG: hsa:126

UniGene: Hs.654537

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