Recombinant Human Aryl hydrocarbon receptor repressor(AHRR)

Code CSB-YP001482HU
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Source Yeast
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Code CSB-EP001482HU
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Source E.coli
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Code CSB-EP001482HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001482HU
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Source Baculovirus
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Code CSB-MP001482HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names AHRR
Uniprot No. A9YTQ3
Alternative Names AHH; AhR repressor; AhRR; AHRR_HUMAN; aryl hydrocarbon hydroxylase regulator; aryl hydrocarbon receptor regulator; Aryl hydrocarbon receptor repressor; Arylhydrocarbon receptor repressor; bHLHe77; Class E basic helix-loop-helix protein 77; Dioxin receptor repressor; KIAA1234; MGC167813; MGC176630; OTTHUMP00000221488; OTTHUMP00000221489
Species Homo sapiens (Human)
Expression Region 1-701
Target Protein Sequence MPRTMIPPGE CTYAGRKRRR PLQKQRPAVG AEKSNPSKRH RDRLNAELDH LASLLPFPPD IISKLDKLSV LRLSVSYLRV KSFFQVVQEQ SSRQPAAGAP SPGDSCPLAG SAVLEGRLLL ESLNGFALVV SAEGTIFYAS ATIVDYLGFH QTDVMHQNIY DYIHVDDRQD FCRQLHWAMD PPQVVFGQPP PLETGDDAIL GRLLRAQEWG TGTPTEYSAF LTRCFICRVR CLLDSTSGFL TMQFQGKLKF LFGQKKKAPS GAMLPPRLSL FCIAAPVLLP SAAEMKMRSA LLRAKPRADT AATADAKVKA TTSLCESELH GKPNYSAGRS SRESGVLVLR EQTDAGRWAQ VPARAPCLCL RGGPDLVLDP KGGSGDREEE QHRMLSRASG VTGRRETPGP TKPLPWTAGK HSEDGARPRL QPSKNDPPSL RPMPRGSCLP CPCVQGTFRN SPISHPPSPS PSAYSSRTSR PMRDVGEDQV HPPLCHFPQR SLQHQLPQPG AQRFATRGYP MEDMKLQGVP MPPGDLCGPT LLLDVSIKME KDSGCEGAAD GCVPSQVWLG ASDRSHPATF PTRMHLKTEP DSRQQVYISH LGHGVRGAQP HGRATAGRSR ELTPFHPAHC ACLEPTDGLP QSEPPHQLCA RGRGEQSCTC RAAEAAPVVK REPLDSPQWA THSQGMVPGM LPKSALATLV PPQASGCTFL P
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Gene References into Functions
  1. Differential methylation was observed in the CYP1A1 promoter and AHRR gene body regions between women who smoked throughout pregnancy and non-smokers on the fetal-side of the placenta and in the GFI1 promoter between women who quit smoking while pregnant and non-smokers on the maternal-side of the placenta PMID: 28820654
  2. For AHRR, exposure to maternal smoking was associated with increased DNA methylation in the placentas of female fetuses; mRNA expression, however, was unchanged. While exposure to maternal smoking was not associated with AHRR DNA methylation changes in fetal livers; mRNA expression was increased. PMID: 29169084
  3. AHRR DNA methylation of cord and maternal blood might be independently associated with full term, low birth weight infants in different ways. PMID: 28454697
  4. DNA methylation at AHRR is associated with smoking. PMID: 28436623
  5. The structure clearly disclosed that AhRR competitively represses AhR binding to ARNT and target DNA and further suggested the existence of an AhRR-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR represses AhR-mediated gene transcription. PMID: 28904176
  6. Prospective study demonstrated that AHRR and F2RL3 methylation levels had inverse relationships with self-reported smoking status and accurately discriminated for both current- and former- smoking. Moreover, methylation markers distinguished former smokers from never-smokers with high accuracy and significantly associated with an increased risk of lung cancer. PMID: 28453567
  7. In conclusion, we found that AHRR (cg05575921) hypomethylation was associated with smoking, high smoking-related morbidity and with high all-cause mortality. PMID: 28100713
  8. The findings suggest that AHRR plays distinct roles in kidney functions and hemoglobin values. PMID: 28485216
  9. Maternal-smoking sensitive CpG sites in newborns were significantly associated with cg05575921 SNP located proximal to AHRR. PMID: 27403598
  10. This study demonstrated that the polymorphisms of aromatic hydrocarbon receptor repressor rs2292596 was significant with genetic susceptibility to rheumatoid arthritis patients; furthermore, it suggests the G allele of aromatic hydrocarbon receptor rs2292596 might be associated with a dangerous effect on rheumatoid arthritis in Han Chinese populations. PMID: 28403070
  11. Study demonstrates that AHRR and F2RL3 methylation are strong predictors individually for lung cancer development. PMID: 27924164
  12. In the AHRRNCOA2 protein, the Cterminal part of AHRR is replaced by the Cterminal part of NCOA2 which contains two activation domains PMID: 27633981
  13. AHRR methylation in monocytes may be a part of the biological link between cigarette smoking and atherosclerosis PMID: 26307030
  14. In conclusion, offspring AHRR DNA methylation was associated with maternal obesity during pregnancy as well as infant gestational age and birth weight-for-gestational age. PMID: 26252179
  15. Knockdown of TiPARP, but not AHRR, increased 2,3,7,8-tetrachlorodibenzo-p-dioxin - induced CYP1A1 mRNA and AHR protein levels. PMID: 24806346
  16. The study expands the region of AHRR methylation altered in response to maternal smoking during pregnancy and reveals the tissue-specific nature of epigenetic responses to environmental exposures in utero. PMID: 24270552
  17. a high frequency of the AhRR SNP can be a risk factor in the incidence of oral cancer and other neoplasias in Papua New Guinea due to higher inducibility of CYP1A2. PMID: 23648678
  18. Selected genetic polymorphisms in the AHR-signaling pathway (i.e., AHRR) and CLOCK may play a role in decreasing the risk for experiencing insomnia during the menopausal transition. PMID: 23768840
  19. TTP directly binds to the AHRR 3'UTR. TTP acts as a negative regulator of AHRR and may affect tumor development through induction of tumor suppressor genes. PMID: 23583445
  20. Aryl hydrocarbon receptor repressor genotypes predict the inducibility of CYP1A2 in people highly exposed to toxic dioxin-like chemicals PMID: 23168330
  21. methylation at AHRR (cg05575921) is associated with smoking status PMID: 23070629
  22. These data clearly indicate that repressed CYP1 activity in primary human skin fibroblasts is not causally related to AhRR expression, which may serve a different, yet unknown, biological function. PMID: 22951721
  23. in primary gastric adenocarcinoma, AHRR may play as a suppressor gene and its expression status has the potential to be an independent prognostic factor PMID: 22952704
  24. a substantial subset of soft tissue angiofibroma is characterized by a t(5;8)(p15;q13), resulting in the expression of in-frame AHRR/NCOA2 and NCOA2/AHRR fusion transcripts. PMID: 22337624
  25. In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis. PMID: 22017422
  26. AHRR methylation is associated with smoking. PMID: 22232023
  27. Pro185Ala polymorphism is weakly associated with micropenis. PMID: 11835227
  28. None of the polymorphisms were found to play a key role in CYP1A1 inducibility or in the susceptibility to develop lung cancer PMID: 12777964
  29. there existed characteristic differences in the basal levels of aryl hydrocarbon receptor repressor and cytochrome P450 1A1 expression in mononuclear cells, as well as in their inducibility among MNCs from various types of human bloods PMID: 14672759
  30. Negative feedback effect of AHRR on dioxin-related signaling is weaker for proline allele than for alanine allele, and hypomorphic function of proline allele exerts recessive adverse effect on male fertility. PMID: 15474075
  31. AHRR Pro185Ala polymorphism may constitute a susceptibility locus for the development of micropenis in response to dioxins. PMID: 15758562
  32. AhRR codon 185 polymorphism is associated with susceptibility to and severity of endometriosis in Japanese women. PMID: 16084889
  33. investigated which roles the AR polymorphisms as well as the R554K and P185A in the AHR and AHRR genes, respectively, may play in modifying the effect of exposure to organohalogen pollutants in regard to sperm Y : X ratio PMID: 17244640
  34. the AhRR codon 185 and GSTT1 polymorphisms are associated with the risk of advanced stage endometriosis PMID: 17513317
  35. AHRR Pro185Ala polymorphism contributed to a predisposition to male factor infertility in the Estonian population. A greater prevalence of the Ala/Ala genotype was found among infertile patients. PMID: 17559847
  36. Suggest role for the AhRR in regulation of CYP1A1. PMID: 17890447
  37. The NLS deletion mutant of GFP-AhRR was transported into the nuclear compartment in the presence of AhR nuclear translocator (Arnt). PMID: 17980155
  38. These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers. PMID: 18172554
  39. Data suggest that the aryl hydrocarbon receptor repressor might play a role of co-repressor on the transcriptional activity of the estrogen receptor alpha homodimer. PMID: 18565642
  40. Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively and may have utility for early detection of esophageal squamous dysplasia and early ESCC. PMID: 19137073
  41. The SUMOylation of both AhRR and Arnt is important for the efficient transcriptional repression activity of the AhRR/Arnt heterodimer PMID: 19251700
  42. Results identify aryl hydrocarbon receptor (AHR) repressor (AHRR) Delta8 as the active form of human AHRR and reveal novel aspects of its function and specificity as a repressor of AHR. PMID: 19380484
  43. AHHR genotyping may help to identify a subpopulation of women who are susceptible to the earlier onset of endometriosis. PMID: 19501819

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Subcellular Location Cytoplasm. Nucleus. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
Tissue Specificity Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomic
Database Links

HGNC: 346

OMIM: 606517

KEGG: hsa:57491

STRING: 9606.ENSP00000323816

UniGene: Hs.50823

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