Recombinant Human Beta-catenin-interacting protein 1(CTNNBIP1)

Code CSB-EP873645HU
Size US$1726
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names CTNNBIP1
Uniprot No. Q9NSA3
Research Area Signal Transduction
Alternative Names Beta catenin interacting protein 1; Beta catenin interacting protein ICAT; Beta-catenin-interacting protein 1; Catenin beta interacting protein 1; CNBP1_HUMAN; CTNNBIP 1; CTNNBIP1; ICAT; Inhibitor of beta catenin and Tcf 4; Inhibitor of beta-catenin and Tcf-4; MGC15093
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-81aa
Target Protein Sequence MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 36.2kDa
Protein Length Full Length
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
Gene References into Functions
  1. Data demonstrated that ICAT was highly expressed in cervical cancer tissues and had a role in control of epithelial-mesenchymal transition (EMT) in cervical cancer cells. Its overexpression promoted cell proliferation, migration, invasion and resulted in EMT by disrupting the stability of E-cadherin/betacatenin complex. PMID: 29048651
  2. Low PLD1 expression and high ICAT expression were significantly associated with increased survival in colorectal cancer patients. PMID: 28939743
  3. The present work aims to investigate the relationship between the expression of AEG-1(astrocyte elevated gene-1), b-FGF(basic-fibroblast growth factor), beta-catenin, Ki-67, TNF-alpha (tumor necrosis factor-alfa) other prognostic parameters in DC (Ductal Carcinomas) and ductal intraepithelial neoplasm. We found a relationship between these factors. PMID: 26096243
  4. Overexpression of ICAT promoted Caski cells' proliferation, arrested the cell cycle in the S phase and enhanced cell migration. Conclusion Overexpression of ICAT can promote the proliferation and migration of Caski cervical cancer cells. PMID: 27774943
  5. Somatic mutation of beta-catenin (CTNNB1) is known to be crucial for Wilms tumor development in up to 15% of cases. PMID: 27679509
  6. CTNNBIP1 expression correlated with longer overall survival in LAC patients. This study reveals that miR-214 plays a critical role in CSLC self-renewal and stemness by targeting CTNNBIP1. PMID: 26299367
  7. Data show that microRNA miR-215 activates beta-catenin pathways by decreasing catenin beta interacting protein 1 (CTNNBIP1)expression in gliomas. PMID: 26317904
  8. Simultaneous silencing of beta-catenin and STAT3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. PMID: 25845340
  9. Finally, pro-incubation with idebenone inhibited mitochondrial dysfunction induced by oxLDL through the mitochondrial-dependent apoptotic pathway and GSK3beta/beta-catenin signalling pathways. PMID: 26284974
  10. A potent beta-catenin inhibitor, ICAT/CTNNBIP1 was a direct target of miR-424-5p. PMID: 25175916
  11. Particulate matter (PM10) downregulates E-Cadherin/beta-Catenin expression. PMID: 26047787
  12. A statistically significant lapatinib- and gefitinib-induced repression of cyclin D1, MMP9 and beta-catenin in CERV196 cells. PMID: 26124325
  13. Nuclear YAP and cytoplasmic beta-catenin play important roles in carcinogenesis. PMID: 26124339
  14. review of control of cell fate and proliferation in colon cancer PMID: 25193262
  15. miR-603 regulates glioma development via Wnt-beta-cateninn signaling pathway and its WIF1 and CTNNBIP1 targets. PMID: 25681036
  16. These results indicate that beta-catenin translation is initiated via the IRES and this is regulated by PTX, suggesting that regulation of the IRES-dependent translation of beta-catenin may be involved in the cancer cell response to PTX treatment. PMID: 25849888
  17. ICAT may serve as a tumor-suppressor in human glioma. PMID: 25434796
  18. Suppressing TrpC5 expression decreased nuclear beta-catenin accumulation, reduced the induction of ABCB1, and reversed 5-fluorouracil neoplastic resistance. PMID: 25404731
  19. Our results indicate that HDAC1 plays an important role in chondrogenesis and may represent a therapeutic target for modulation of cartilage development. PMID: 25445594
  20. ASPP2 prevents beta-catenin from transactivating ZEB1 directly by forming an ASPP2-beta-catenin-E-cadherin ternary complex PMID: 25344754
  21. It involved in the control of cell growth, differentiation, and apoptosis. PMID: 24390805
  22. PTHrP was found to inhibit DKK1 expression through c-Jun-mediated inhibition of beta-catenin activity on the DKK1 promoter. PMID: 23752183
  23. beta-catenin inhibitor ICAT modulates the invasive motility of melanoma cells. PMID: 24514042
  24. Neither cyclin D1 nor beta-catenin was expressed in a statistically significant manner, concluding that the development of MCCs is independent of beta-catenin and cyclin D1 expression and these proteins are not suitable as prognostic markers. PMID: 23928935
  25. beta-catenin is delocalized and survivin is over-expressed in recurrent sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor PMID: 23572266
  26. Thus, our results indicated abnormal expression of CD44V6, CDH11, and beta-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research. PMID: 23971040
  27. The data show that Snail1 and beta-catenin, besides association with loss of hormone dependence, protect cancer cells from hypoxia and may serve as an important target in the treatment of breast cancer. PMID: 23973669
  28. This study demonistrated that mean protein and mRNA levels of beta-catenin were significantly decreased in both the PFC and hippocampus of teenage suicide group compared to controls. PMID: 23110823
  29. beta-catenin accumulation in the nucleus regulates expression of Nanog protein and has a role in progression of non-small cell lung cancer PMID: 23648139
  30. These findings suggest that Sphingosine-1-phosphate activates signaling leading to nuclear translocation of beta-catenin in osteoblast-like cells and upregulation of osteoptotegerin and osteoblast differentiation markers PMID: 23612487
  31. beta-catenin was significantly associated with nodal stage, TNM stage, and E-cadherin expression. beta-catenin could be early marker for identification of occult metastases in oral SCC. PMID: 22525043
  32. In this review, we will discuss the points of intersection between the Wnt/beta-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis. PMID: 23027379
  33. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression. PMID: 23339455
  34. our data clearly identify protein stabilizing mutations of the beta-catenin gene as a common feature of nested stromal epithelial tumors of the liver, similarly as in hepatoblastomas. PMID: 22749188
  35. Microatellite-stable cases exhibited reduced membranous beta catenin and increased cytoplasmic and nuclear beta catenin compared with microsatellite-instable cases. PMID: 21791486
  36. Airway basal cell beta-catenin determines cell fate and its mis-expression is associated with the development of human lung cancer. PMID: 22081448
  37. Cholangiocarcinoma cell lines express E-cad and beta-cat but with different localizat- ion patterns. PMID: 22075503
  38. Inhibitor of beta-catenin and T-cell factor (ICAT), a beta-catenin binding protein that inhibits the canonical Wnt/beta-catenin signaling pathway, in AR signaling, was investigated. PMID: 21885566
  39. Reduced/aberrant beta-catenin expression was seen in benign and malignant salivary gland tumors. PMID: 20034989
  40. ICAT is a direct transcriptional target of E2F1, and activation of ICAT by E2F1 is required for E2F1 to inhibit beta-catenin activity. PMID: 21532622
  41. overexpression of beta-catenin may be an important contributing factor to glioma progression. PMID: 20300972
  42. High beta-catenin is associated with glioma progression. PMID: 21636708
  43. LMP1 may be involved in nasopharyngeal carcinogenesis via beta-catenin signaling pathway PMID: 21336584
  44. A coactivator role of CARM1 in the dysregulation of beta-catenin activity in colorectal cancer cell growth and gene expression PMID: 21478268
  45. When both E-cadherin and beta -catenin expressions were reduced, there was a significant unfavourable prognosis. PMID: 21574102
  46. The protein expression levels of Wnt1, beta-catenin and Cyclin D1 were all positively correlated with the Karnofsky performance scale (KPS) score and World Health Organization (WHO) grades of patients with gliomas. PMID: 20809334
  47. beta-catenin is expressed in actinic chelitis and squamous cell carcinoma of the lip PMID: 20970365
  48. Data show that elevated beta-catenin expression level may be an adverse indicator for the prognosis of ESCC patients at stage T2-3N0M0, especially for those with T3 lesions or stage IIB diseases. PMID: 21049553
  49. cytoplasmic accumulation of beta-catenin can induce Tcf/Lef-mediated transcriptional activity, up-regulate MMP-7, and induce epithelial and mesenchymal transition (EMT). PMID: 20878057
  50. our results support the concept that STAT3 upregulates the protein expression and transcriptional activity of beta-catenin in breast cancer. PMID: 20830236

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Subcellular Location Cytoplasm, Nucleus
Protein Families CTNNBIP1 family
Database Links

HGNC: 16913

OMIM: 607758

KEGG: hsa:56998

STRING: 9606.ENSP00000366466

UniGene: Hs.463759

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