Recombinant Human C-type lectin domain family 4 member K(CD207),partial

Code CSB-YP892321HU
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Source Yeast
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Code CSB-EP892321HU
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Source E.coli
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Code CSB-EP892321HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP892321HU
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Source Baculovirus
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Code CSB-MP892321HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CD207
Uniprot No. Q9UJ71
Alternative Names C type lectin domain family 4 member K; C-type lectin domain family 4 member K; CD 207; CD207; CD207 antigen; CD207 antigen; langerin; CD207 molecule; CLC4K_HUMAN; CLEC 4K; CLEC4K; Langerhans cell specific c type lectin; Langerin; RGD1565913
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Gene References into Functions
  1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form. PMID: 29631057
  2. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo. PMID: 28847997
  3. the data provide evidence that human Langerhans cells are able to cross-present antigens after langerin-mediated internalization. PMID: 26456691
  4. Calcium-independent activation of an allosteric network in langerin by heparin oligosaccharides has been reported. PMID: 28198086
  5. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent PMID: 27903635
  6. Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin PMID: 27447199
  7. We suggest that CD207 gene polymorphisms rs13421115 and rs17718987 increase the risk of development of end-stage renal disease. PMID: 27234728
  8. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies and further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility. PMID: 24676666
  9. This study is the first to demonstrate that langerin represents an authentic receptor that binds and internalizes influenza A virus to facilitate infection. PMID: 26468543
  10. Data suggest that Langerin (CD207)-mediated binding of Yersinia pestis to antigen-presenting cells (APCs) may promote its dissemination and infection. PMID: 25829141
  11. Langerin binds heparin (HEP)-like oligosaccharides in two different binding sites depending on the ligand size. PMID: 25747117
  12. The authors not only show that langerin and caveolin-1 co-localize at the cell membrane and in vesicles but that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection. PMID: 25551286
  13. The impact of two carbohydrate recognition domains mutations, W264R and F241L, on langerin structure, function, and Birbeck granules assembly. PMID: 25650933
  14. Langerin is not expressed by freshly isolated CD1c(+) blood DCs but is rapidly induced on CD1c(+) DCs by serum or TGF-beta via an ALK-3-dependent pathway. PMID: 25516751
  15. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103 PMID: 25584868
  16. However, the superoxide dismutase C (SodC) protein of the Mycobacterium leprae cell wall was identified as a langerin-reactive ligand. PMID: 25422308
  17. Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog. PMID: 25070850
  18. Altered langerin function in individuals with the linked N288D and K313I polymorphisms may affect susceptibility to infection by microorganisms. PMID: 24217250
  19. binding properties of langerin PMID: 23226363
  20. A langerin-cre recombinase transgenic knockin mouse strain is generated that efficiently targets Langerhans cells and other langerin-positive dendritic cells, in particular, in the dermis and the lung. PMID: 21998450
  21. measles virus receptor on Langergans cells PMID: 21739428
  22. Unlike selective Langerhans cell deficiency, ablation of all langerin-positive dendritic cells abrogates activation of IFN-gamma-producing and cytolytic CD8-positive T cells following gene gun vaccination. PMID: 21187444
  23. Crystal structures of the carbohydrate-recognition domain from langerin bound to oligomannoses, blood group B antigen, and a fragment of beta-glucan reveal binding to mannose, fucose, and glucose by Ca(2+) coordination of hydroxyl groups. PMID: 21112338
  24. Activation of CD8-positive T cells following intradermal plasmid DNA immunization depends on directly transfected langerin-positive dermal dendritic cells and dermal DCs. PMID: 20713888
  25. Trimeric structure of langerin. PMID: 20181944
  26. Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain PMID: 20026605
  27. Langerin is the major fungal pathogen receptor on human Langerhans cells that recognizes pathogenic and commensal fungi. PMID: 20097424
  28. Data show that the expression of CD1a and CD207 is markedly down-regulated in CA epidermis. PMID: 19426597
  29. In a transgenic mouse model, the langerin-expressing subset of CD8alpha-positive dendritic cells is crucially involved in priming and differentiation of responses to cross-presented antigen. PMID: 19923446
  30. langerin was expressed by Langerhans cells PMID: 12352970
  31. Langerin is a potent langerhans cells -specific regulator of membrane superimposition and zippering, representing a key molecule to trace Langerhans cells [Review]. PMID: 14610287
  32. CD1a and langerin have roles in antigen presentation to T cells PMID: 14991068
  33. The Langerin-positive cells strictly colonized the epidermis and no cells were found in the dermis. PMID: 15222130
  34. Expression of mutated Langerin in human fibroblasts induces tubular-like structures that are negative for Birbeck granules-specific antibodies and do not resemble the characteristic structural features of Birbeck granules. PMID: 15816828
  35. Electron microscopy analysis demonstrated a colocalization of human papillomavirus 16 virus-like particles and langerin, which is expressed only by Langerhans cells PMID: 15831940
  36. The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms. PMID: 16567809
  37. Langerin prevents HIV-1 transmission by Langernhans cells. PMID: 17334373
  38. Langerin transgenic mice have substantially reduced numbers of epidermal langerhans cells, demonstrating that TGFbeta1 acts directly on these cells. PMID: 17938236
  39. The carbohydrate-recognition domain of human Langerin was crystallized followed by X-ray analyses to resolutions of 2.5A for apo-Langerin and to 1.6A and 2.1A for the complexes with mannose and maltose, respectively. PMID: 18061677
  40. overproduction, purification and crystallization of the langerin carbohydrate binding domain is reported PMID: 18259063
  41. Immunohistochemical evaluation of langerin expression may have utility in substantiating a diagnosis of Langerhans cell histiocytosis and separating this disorder from other non-Langerhans cell histiocytic proliferations. PMID: 18277880
  42. Transgenic langerin effectively mediates antigen presentation in vivo by targeting its receptor in appropriate mouse dendritic cell subsets of draining lymph nodes and spleen; peptide major histocompatibility I and II complexes persist for days. PMID: 18322168

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Involvement in disease Birbeck granule deficiency (BIRGD)
Subcellular Location Membrane; Single-pass type II membrane protein. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Database Links

HGNC: 17935

OMIM: 604862

KEGG: hsa:50489

STRING: 9606.ENSP00000386378

UniGene: Hs.199731

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