Recombinant Human CCAAT/enhancer-binding protein epsilon (CEBPE)

1. CEBPE expression was highest in multipotent progenitor cells (S1) and declined sharply as cells progressed to B-cell-committed progenitors, including pre-B-I cells (S2), pre-B-II cells (S3) and immature B cells (S4) PMID: 26437776
2. Data show that both CEBPE and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD) abolish the interaction with SWI/SNF and secondary granule gene expression, thus providing a molecular basis for this disease. PMID: 28369034
3. PML/RARalpha synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia differentiation and potentially, clinical remission. PMID: 27605212
4. the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. PMID: 28476190
5. The minor allele of the CEBPE variant associated with lower basophil count has been previously associated with Amerindian ancestry and higher risk of acute lymphoblastic leukemia in Hispanics. PMID: 28158719
6. identified the rs45496295 (C > T) polymorphism in the heterozygous state in 73.9% of beta-thalassemia intermedia patients. PMID: 27829304
7. variants within IKZF1, ARID5B, and CEBPE were associated with pediatric ALL risks. PMID: 27184773
8. Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1-rs4132601 (p=0.039, p=0.015) and ARID5B-rs10821936 (p=0.028, p=0.026). PMID: 27644650
9. variants within IKZF1, ARID5B, and CEBPE were associated with increased acute lymphoblastic leukemia (ALL) risk, and the effects for ARID5B and CEBPE were most prominent in high-hyperdiploid ALL subtype in the California Hispanic population PMID: 25761407
10. Data indicate no significant associations of transcription factors rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) with risk of pediatric non-Hodgkin lymphoma (NHL). PMID: 25005032
11. our study provided evidence that CEBPE rs2239633 variant is associated with decreased risk of childhood B-cell ALL in Europeans. PMID: 25938438
12. A novel in-frame deletion in the leucine zipper domain of CEBPE leads to neutrophil-specific granule deficiency. PMID: 26019275
13. During neutrophil development, acetylation of lysines 121 and 198 were found to be crucial for terminal neutrophil differentiation and the expression of neutrophil-specific granule proteins, including lactoferrin and collagenase. PMID: 25568349
14. Studies indicate that the CCAAT/enhancer binding protein-epsilon (CEBPE) rs2239633 polymorphism was significantly associated with childhood acute lymphoblastic leukemiaacute lymphoblastic leukemia (ALL) risk. PMID: 25195121
15. study found that previously identified childhood acute lymphoblastic leukemia susceptibility loci in ARID5B and CEBPE show consistent risk effects across both Hispanic and non-Hispanic White populations, providing compelling supportive evidence for susceptibility at these loci PMID: 23836053
16. Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group. PMID: 24497567
17. miR-130a is important for the regulation of the timed expression of C/EBP-epsilon during granulopoiesis. PMID: 24398327
18. rs2239632 could regulate the expression of the CEBPE gene. Its risk allele (G) might increase the gene product and lead to leukemogenesis. A person with the allele or the corresponding haplotype might have increased susceptibility to ALL. PMID: 23719191
19. rs4132601 in IKZF1 and rs2239633 in CEBPE are not significantly related to childhood childhood acute lymphoblastic leukemia. PMID: 23608171
20. Case provides the first evidence that chromosome duplication and cryptic insertion produce the CEBPE-IGH fusion and that more than one CEBPE-IGH recombination can occur in a leukemic cell. PMID: 22137487
21. The results above collectively show that C/EBPepsilon participates in all-trans retinoic acid induction of PI3Kgamma. PMID: 20661648
22. causative agent in the development of Neutrophil specific granule deficiency PMID: 11753076
23. Interacts with other transcription factors to regulate transcription of the gene encoding eosinophil granule major basic protein PMID: 12202480
24. C/EBP epsilon is essential and sufficient for the expression of a particular subset of neutrophil secondary granule genes. PMID: 12515729
25. Upon induction of maturation, C/EBP epsilon binds to the lactoferrin (LF) promoter, which correlates with LF expression. PMID: 12522000
26. overexpression of C/EBPepsilon in myeloid cells leads to down-regulation of c-Myc PMID: 12947005
27. Retinoic acid signaling in granulocytic differentiation involves regulated expression of CHOP protein and C/EBPepsilon in a coordinated fashion. PMID: 15308577
28. Our data suggest that ATRA-induced regulation of Stat2, ICSBP and C/EBPepsilon is dependent on active Stat1, and that a failure to correctly regulate these transcription factors is associated with the inhibition of monocytic differentiation. PMID: 16918696
29. Decreased Gfi-1 levels in our SGD patient, together with the mutant C/EBPepsilon, block secondary granules proteins expression, thereby contributing to the underlying etiology of the disease in our patient. PMID: 17244686
30. Interaction of the activated NFkappaB pathway and C/EBP-epsilon may be important in selective activation of a subset of C/EBP-epsilon-responsive genes. PMID: 17255362
31. The type IV isoform of PML interacted with PU.1, promoted its association with p300, and then enhanced PU.1-induced transcription and granulocytic differentiation and PU.1 directly activates the transcription of the C/EBPepsilon gene. PMID: 17562868
32. C/EBP epsilon is a critical transcription factor for tumor necrosis factor alpha-induced up-regulation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression in non-differentiated HL60 cells. PMID: 17688422
33. C/EBP- isoforms can reprogram myeloid lineage commitment and differentiation consistent with their predicted activities based on activator and repressor domains and in vitro functional activities PMID: 18832658
34. Substantial quantitities of C-EBPepsilon are expressed in human neutrophils, especially the p14 and p32 variants. PMID: 19109189

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HGNC: 1836

OMIM: 245480

KEGG: hsa:1053

STRING: 9606.ENSP00000206513

UniGene: Hs.558308