Recombinant Human Early growth response protein 3 (EGR3 PILOT)

1. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
2. miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC PMID: 28070994
3. EGR3 contributes to cell growth inhibition via upregulation of FasL in Hepatocellular carcinoma. PMID: 28098878
4. These findings support previously reported associations between EGR3 and schizophrenia. PMID: 26474411
5. EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer. PMID: 25633035
6. Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China PMID: 24886494
7. Genetic variation in EGR3 may affect prefrontal function through neurodevelopment PMID: 23962955
8. These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses. PMID: 23906810
9. Decreased EGR3 expression might play a critical role in the differentiation, proliferation, metastasis and progression of gastric cancer cells. PMID: 23460371
10. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter. PMID: 23935197
11. Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity PMID: 23904169
12. Egr3 mRNA expression reveals that Egr3 mRNA expression is increased in tumor cells of non-relapsed samples compared to normal prostate cells, but is significantly lower in relapsed samples compared to non-relapse. PMID: 23342084
13. EGR3, a gene that translates environmental stimuli into long-term changes in the brain, may be associated with risk for child bipolar disorder 1. PMID: 22370066
14. Study supports the association of EGR3 with schizophrenia in Han Chinese sample. PMID: 22276163
15. EGR3 gene may play an important role in schizophrenia susceptibility PMID: 22425949
16. EGR3 bound to the TREM-1 promoter. PMID: 21421043
17. This study demoistrated that ERG3 are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
18. SNP rs35201266 in intron 1 of the EGR3 gene showed a significant association with schizophrenia PMID: 20687139
19. Egr-3 is a critical determinant of VEGF signaling in activated endothelial cells PMID: 19965691
20. Vascularendothelial growth factor induces expression of NR4A nuclear receptors and Egr3 via KDR and KDR-mediated signaling mechanisms. PMID: 14525795
21. data suggest that Egr3 is a target for the estrogen receptor alpha PMID: 15171706
22. These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene. PMID: 17360599
23. findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease PMID: 18059339
24. Enforced expression of Egr3 transgene, from the CD2 antigen promoter, facilitates development of RAG2-deficient double-negative (DN) stage 3 thymocytes to the DN4 stage and subsequently to the double-positive stage of development. PMID: 19124717

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HGNC: 3240

OMIM: 602419

KEGG: hsa:1960

STRING: 9606.ENSP00000318057

UniGene: Hs.534313