Recombinant Human FACT complex subunit SSRP1 (SSRP1 FACT80)

1. Data revealed that SSRP1 is highly overexpressed in glioma tissues at both the mRNA and protein levels and correlated with tumor grade. Further analysis demonstrated that that SSRP1 regulates the proliferation and metastasis of glioma cells via the MAPK signaling pathway. PMID: 29048646
2. These data uncover a previously unknown role for SSRP1 in promoting the activation of the Wnt signaling pathway activity during cellular differentiation. PMID: 27146025
3. we propose that FACT is both a marker and a target of aggressive breast cancer cells, whose inhibition results in their death or conversion a less aggressive subtype PMID: 28423528
4. High FACT expression is associated with glioblastoma. PMID: 27370399
5. The association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 in HIV-1 infection. PMID: 27216501
6. Results show that SSRP1 upregulation contributed to hepatocellular carcinoma development and the tumor-suppressive miR-497 served as its negative regulator. PMID: 26755331
7. FACT chaperone stabilizes the soluble CENP-T/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T/-W deposition at centromeres. PMID: 27284163
8. This discloses a novel property of FACT wherein it has a co-remodeling activity and strongly enhances the remodeling capacity of the chromatin remodelers. Altogether, our data suggest that FACT may acts in concert with RSC to facilitate excision of DNA lesions during the initial step of BER. PMID: 27467129
9. SSRP1/Ets-1/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel. PMID: 27525970
10. Our studies facilitate the understanding of SSRP1 and provide insights into the molecular mechanisms of interaction with DNA and histones of the FACT complex. PMID: 26687053
11. AID accesses the H2B N-terminal basic region exposed by partial unwrapping of the nucleosomal DNA, thereby triggering the invasion of FACT into the nucleosome PMID: 26966247
12. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage. PMID: 26842758
13. FACT, NF-kappaB, and cell-cycle progression are inhibited by quinacrine, which overcomes resistance to erlotinib in non-small cell lung cancer PMID: 25028470
14. EEF1A1, SSRP1, and XRCC6 are novel interacting partners of the mineralocorticoid receptor PMID: 25000480
15. A primary role for FACT in RNF20 recruitment chromatin remodeling for initiation of homologous recombination repair. PMID: 24357716
16. In the absence of FACT complex, SSRP1 and SPT16 mRNAs are unstable and inefficiently translated, making reactivation of FACT function unlikely in normal cells. PMID: 23839038
17. hFACT-H2A/H2B interactions play a key role in overcoming the nucleosomal barrier by Pol II and promoting nucleosome survival during transcription PMID: 23610384
18. SETD2 activity modulates FACT recruitment and nucleosome dynamics, thereby repressing cryptic transcription initiation. PMID: 23325844
19. The HSF1-RPA complex leads to preloading of RNA polymerase II and opens the chromatin structure by recruiting a histone chaperone, FACT PMID: 22940245
20. specific FACT subunits synchronize interactions with various target sites on individual nucleosomes to generate a high affinity binding event and promote reorganization. PMID: 21969370
21. DNA-PK and FACT both play roles in DNA repair. Therefore both are putative targets for therapeutic inhibition. PMID: 21679440
22. The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. PMID: 21454601
23. Studies suggest that that even though FACT has rapid chromatin-binding activity, the binding pattern of FACT on chromatin changes after origin licensing, which may contribute to the establishment of its functional link to the DNA replication machinery. PMID: 21232560
24. results demonstrate that SSRP1 is crucial for microtubule growth and spindle assembly during mitosis. PMID: 19995907
25. SSRP1 stimulates p63 activity by associating with this activator at the promoter PMID: 12374749
26. CK2 regulates the DNA-binding ability of SSRP1 and that this regulation may be responsive to specific cell stresses. PMID: 15659405
27. These results demonstrate that SSRP1 degradation during apoptosis is a two-step process coupling caspase cleavage and ubiquitin-dependent proteolysis. PMID: 16498457
28. SSRP1 has Spt16-dependent and -independent roles in regulating gene transcription in human cells. PMID: 17209051
29. CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1. PMID: 19625449
30. SSRP1 may play a role in the DNA damage response mediated by homologous recombination; SSRP1 physically interacts with a key recombination repair protein, Rad54 PMID: 19639603
31. These results indicate that SSRP1 is a novel cellular protein involved in LANA-dependent DNA replication. PMID: 19710137
32. occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918

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HGNC: 11327

OMIM: 604328

KEGG: hsa:6749

STRING: 9606.ENSP00000278412

UniGene: Hs.523680