Recombinant Human Glutathione S-transferase omega-2 (GSTO2)

1. the effect of specific GSTO1 and GSTO2 gene variants, independently and in interaction with established risk factors (smoking, obesity and hypertension) on the risk for the most aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC, is reported. PMID: 30224590
2. Results showed that the variants of rs156697 and rs2297235 of GSTO2 provide the susceptibility toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China. PMID: 29323258
3. GSTO2 genetic polymorphisms are not associated with the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. PMID: 26103006
4. The GSTO2 rs2297235 "AG" genotype is associated to SCA2 but failed to show any association with clinical markers, with the exception of a potential association with the age at disease onset. PMID: 28017238
5. GSTO2 genetic polymorphisms are associated with the progression of HBV infection. PMID: 27221910
6. No significant association has been found between childhood Pre-B acute lymphoblastic leukemia and GSTO1 A140D and GSTO2 N142D polymorphisms. PMID: 25726706
7. GSTO2 and GSTP1 gene polymorphisms may serve as independent prognostic markers for hepatocellular carcinoma patients. PMID: 25892883
8. Our results indicate that GSTO1*C/GSTO2*G haplotype is associated with increased risk of TCC. The modifying effect of GSTO2*G/G genotype on individual susceptibility to TCC is more pronounced, when associated with smoking. PMID: 25716313
9. we for the first time provided evidence supporting the prognostic role of GSTO2 in the progression of TACE-treated hepatocellular carcinoma PMID: 25835968
10. The GSTA1*-69T and GSTO2*D142 variants are both associated with a significantly increased risk of asthma. PMID: 24471578
11. The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development. PMID: 23927022
12. GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. PMID: 24040330
13. No significant association between GSTO2 polymorphism and acute renal graft rejection. PMID: 23649768
14. Variants in human GSTO2 could increase disease risk susceptibility and could act as a risk factor for hypothyroidism in Italian patients. PMID: 23079717
15. The frequencies of GSTO1 and GSTO2 genotypes were not significantly different between head and neck squamous cell carcinoma cases and controls. PMID: 23086268
16. The polymorphisms of GSTM1 and GSTO2 along with the work place influence may act additively for developing cataract. PMID: 22876127
17. GSTA1 and the GSTO2 are asthma susceptible genes involved in increasing the risk of asthma development in the Italian population PMID: 22040239
18. Found that rs156697 minor allele of GSTO2 associates with increased risk in the older ADs with age-at-diagnosis > 80 years. The minor alleles of GSTO1 rs4925 and GSTO2 rs156697 associate with lower brain levels of GSTO2, but not GSTO1. PMID: 22494505
19. crystal structures of human GSTO2-2, stabilized through site-directed mutagenesis and determined at 1.9 A resolution in the presence and absence of glutathione PMID: 22522127
20. CYP2D6 (rs16947) and GSTO2 (rs156697) polymorphisms are independent factors influencing complete remission rates of the first induction chemotherapy in de novo AML patients. PMID: 21518482
21. GSTO2 NN genotype increase the risk of colorectal cancer in persons with positive family history for cancer in the first degree relatives. PMID: 21113667
22. Has a role in the risk of Urothelial carcinogenesis PMID: 21094982
23. Subjects who had the GSTO2 homozygous D142 genotype were found to have an increased risk of asthma PMID: 20374258
24. This study provides the allele frequencies of GSTO polymorphism in a sample consisting of 116 apparently healthy individuals of both sexes from Rome (Central Italy). PMID: 20113212
25. 142Asp allozyme could modulate arsenic biotransformation and thereby arsenic toxicity PMID: 20045512
26. the frequencies of GSTA1 (glutathione S-transferase alpha 1), GSTM1(GST mu 1 ), GSTO2(GST omega 2) and GSTT1(GST theta 1) genotypes found in asthmatic patients differ from those of controls PMID: 20367187
27. it is unlikely that glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 participate in breast cancer susceptibility. PMID: 19859803
28. Genetic polymorphisms in GSTM1, GSTO2, XRCC1 at codons 194 and 399 may act additively for developing breast cancer PMID: 19731014
29. The Asn142Asp polymorphism in GSTO2 and the GSTO1-140Asp/GSTO2-142Asp haplotype were associated with increased risk of COPD. GSTO2 is a candidate gene for COPD, but is not associated with FEV(1). PMID: 19513904
30. The genetic polymorphism of GSTT1, GSTM1 and GSTO2 N412D in three Iranian populations was detected. PMID: 19430957
31. polymorphisms in GSTO1 or GSTO2 do not appear to contribute to the large individual variability in arsenic metabolism or susceptibility to arsenicosis. PMID: 19635583
32. Our results do not confirm an association between PD and frequency of the polymorphisms investigated: hGSTO1*A140D, & hGSTO1*E155del. PMID: 15159516
33. no association either with age-at-onset in AD cases or with disease risk in the case-control cohort but haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04) PMID: 15917099
34. molecular cloning; GSTO2 was ubiquitously expressed at a low level, with a higher expression in pancreas and prostate PMID: 15942673
35. a glutathione S-transferase omega 2 gene polymorphism may havea role in ovarian cancer PMID: 16761626
36. Differences in expression at the protein level of the major splice variant of GSTO2 suggests that this enzyme is less active in human cells compared with chimpanzee cells. PMID: 17978102
37. GSTO2 DD genotype was associated with decreased risk as compared to GSTO2 NN genotype (OR = 0.21, 95% CI: 0.05-0.92, P = 0.038) PMID: 18398695
38. These results suggest a possible effect of the GSTO1 and 2 locus on age of onset of FALS. PMID: 18427999
39. GSTO1*A140D polymorphism is significantly associated with susceptibility to childhood acute lymphoblastic leukemia. PMID: 18941778
40. Report GSTO2 gene polymorphisms in worldwide populations. PMID: 18986335
41. Our findings suggest that a significantly joint effect of cigarette smoking, alcohol consumption, arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma was found. PMID: 19686770

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HGNC: 23064

OMIM: 612314

KEGG: hsa:119391

STRING: 9606.ENSP00000345023

UniGene: Hs.107384