Recombinant Human Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1), partial

1. Experiments confirmed that GBF1 is required for hepatitis E virus replication. PMID: 29112323
2. Study provides evidence that GBF-1 is required in endoplasmic reticulum structure and endosomal traffic. PMID: 23840591
3. GBF1 could regulate different metabolic pathways through the activation of different pairs of Arf proteins. PMID: 26814617
4. Oligomerization appears to stabilize GBF1 in cells. PMID: 26718629
5. GBF1 plays a critical role early in dengue infection that is independent of its role in the maintenance of Golgi structure. PMID: 24855065
6. The role of GBF1 in poliovirus replication is independent of its Arf activating function. PMID: 25653442
7. Although human rhinovirus 3A protein was previously shown to interact with ACBD3, these data suggest that PI4KIIIbeta recruitment occurred independently of both GBF1 and ACBD3. PMID: 25410869
8. GBF1 causes increased Arf-GTP production at the Golgi, consistent with a feed-forward self-limiting mechanism of Arf activation. PMID: 24213530
9. These data suggest that AMPK-GBF1-Arf1 signaling is involved in the regulation of Golgi fragmentation during mitosis. PMID: 23418352
10. an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum. PMID: 23386609
11. GBF1-mediated Arf1 activation is necessary to unify cell polarity during chemotaxis PMID: 22573891
12. the vesicular transport proteins ARF1 and GBF1 colocalized with PI4KIIIbeta and were both required for HCV replication PMID: 22359663
13. The GBF1 participated in delivery of adipose triglyceride lipase (ATGL) onto the lipid droplets(LD) surface PMID: 22185782
14. We hypothesize that sphingomyelin acquired by CERT-dependent transport of ceramide and subsequent conversion to SM is necessary for C. trachomatis replication whereas SM acquired by GBF1-dependent pathway is essential for inclusion growth and stability. PMID: 21909260
15. The COG (conserved oligomeric Golgi) complex plays a role in the localization, but not membrane association of GBF1. PMID: 21722633
16. GBF1 and ATGL interact directly and in cells, through multiple contact sites on each protein. PMID: 21789191
17. The brefeldin A block of poliovirus replication is rescued by expression of only the N-terminal region of GBF1 lacking the Sec7 domain. PMID: 20497182
18. COPII is the only coat required for sorting and export from the endoplasmic reticulum exit sites, whereas GBF1, but not BIGs, is required for COPI recruitment, Golgi subcompartmentalization, and cargo progression to the cell surface. PMID: 18003980
19. Both human and canine GBF1 can be inhibited by compound LG186, a small molecule derived from Exo2, a small molecule inhibitor of secretion and Shiga toxin cytotoxicity. PMID: 20854417
20. Data suggest that Rab1 contributes to the specificity and timing of GBF1 recruitment by activating PI4KIIIalpha, and that the PtdIns(4)P produced then allows GBF1 to bind to Golgi membranes and activate Arf1. PMID: 20530568
21. The authors demonstrate that Rab1b-activated GBF1 and ARF1 are involved in Ebolavirus virion formation, suggesting that both the COPII and COPI transport systems play a role in Ebolavirus VP40-mediated particle formation. PMID: 20164217
22. Data propose that the phosphorylation and membrane dissociation of GBF1 and the consequent reduction in ARF-GTP levels in mitosis are important for changes in Golgi dynamics PMID: 20175751
23. GBF1 is a cellular factor required for HCV infection. PMID: 19906930
24. detailed subcellular localization to the cis-Golgi PMID: 12047556
25. novel interaction between p115 and Golgi-specific brefeldin-A-resistant factor 1 (GBF1) PMID: 12634853
26. characterization of alternatively spliced and truncated forms of GBF1 defines regions important for activity PMID: 12646181
27. an Arf1-GBF1-Brefeldin A complex is formed and has a longer residence time on Golgi membranes than GBF1 or Arf1 alone PMID: 15616190
28. A continuous cycle of recruitment and dissociation of GBF1 to membranes is required for sustained ARF activation and COP I recruitment that underlies ER-Golgi traffic. PMID: 15813748
29. GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6 PMID: 16318580
30. These observations strongly suggest that GBF1 regulates COPI membrane recruitment in the early secretory pathway. PMID: 16926190
31. Two different poliovirus proteins independently recruit different Arf GEFs (GBF1 and BIG1/2) to membranes as part of cellular pathways utilized by the virus to form its membranous replication complex. PMID: 17079330
32. analysis of the binding domain in GBF1 showed that the extreme N terminus, the dimerization/cyclophilin binding domain, and the homology upstream of Sec7 domain are required for the interaction with coxsackievirus protein 3A PMID: 17329336
33. These data support a model where Rab1b-GTP induces GBF1 recruitment at the ERES interface and at the Golgi complex where it is required for COPII/COPI exchange or COPI vesicle formation, respectively. PMID: 17429068
34. Required for GGA adaptor protein recruitment to Golgi membranes; plays a role in the proper processing and sorting of lysosomal cargo. PMID: 17666033
35. These findings suggest that a secretory pathway capable of trafficking soluble proteins can be maintained in cells in which COPI recruitment is compromised by GBF1 depletion. PMID: 17956946
36. GBF1 is a AMPK substrate and AMPK-mediated phosphorylation of GBF1 at Thr(1337) has a critical role, presumably by attenuating function of GBF1, in disassembly of the Golgi apparatus induced under stress conditions that lower the intracellular ATP PMID: 18063581
37. Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1. PMID: 18287014
38. GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1 PMID: 18524849
39. siRNAs demonstrate that GBF1-mediated ARF1 activation is required for efficient MHV RNA replication PMID: 18551169
40. AG1478 inhibits GBF1, a large nucleotide exchange factor for the ADP-ribosylation factor, in a Sec7 domain-dependent manner and mimics the phenotype of a GBF1 mutant that has an inactive mutation PMID: 18799457
41. GBF1 is responsible for the sensitivity of poliovirus infection to BFA, and is required for virus replication PMID: 19023417
42. crucial for coxsackievirus B3 RNA replication PMID: 19740986

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HGNC: 4181

OMIM: 603698

KEGG: hsa:8729

STRING: 9606.ENSP00000359000

UniGene: Hs.290243